Aim: The purpose of this study was to investigate in-vitro the retreatability of premixed calcium-silicate-based sealer versus resin-based sealer when combined with gutta-percha using the single-file system XP-endo Rise. Materials and methods: 26 canals in typodont acrylic Nissin teeth were instrumented with E-flex blue rotary instruments up to size 0.35mm and taper of 4%. Root canals were divided into two groups, obturated using either hydraulic condensation technique with a bioceramic sealer (n=13) or continuous wave of compaction (CWC) technique with a resin-based sealer (n=13). The retreatment procedure was done for both groups using the XP-endo Rise instruments. The time required to complete the retreatment procedures was recorded in seconds. Cone beam computed tomography (CBCT) was used to assess the obturation material left after retreatment. Retreatment time results were analyzed statistically using an independent t-test, and number of canals with total filling material removal were compared between groups using Fisher's exact test, with a significance level (α) set to 0.05. Results: Patency was achieved in all samples. The retreatment time was longer for canals filled with the bioceramic-based sealer compared with the resin-based sealer (p < 0.05). However, the total number of canals with filling remnants were significantly more in the resin-based sealer group compared to the bioceramic-based sealer group, (p < 0.05). Conclusion: The bioceramic sealer used with the hydraulic condensation technique was effectively retreated, leaving no residual material, even though the retreatment time demonstrated a noticeably longer duration compared to the resin-sealer used with the CWC technique.