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Effect Of Zinc Oxide and Selenium Nanoparticles on Milk Production Efficiency and Related Gene Expression in Egyptian Baladi Goats

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

Biochemistry

Abstract

This study assessed the impact of oral administration of zinc oxide (ZnO) and selenium (Se) nanoparticles on milk production and gene expression in Baladi goats. Twenty-two pregnant females, 30 days before parturition, were divided into five groups: Group 1 (n=4) served as control; Groups 2 and 3 (n=4 each) received 150 mg ZnO and 0.3 mg of Se in microparticle (MP) forms, respectively; Groups 4 and 5 (n=5 each) received 15 mg ZnO and 0.03 mg Se in nanoparticle (NP) forms, respectively. Milk yield, composition, and gene expression related to milk production were analyzed. Results indicated a significant increase (P<0.001) in dry matter intake in the ZnO-NPs and Se-NPs groups, with an improved feed conversion ratio. Daily and overall milk yield, as well as fat-corrected milk yield, were highest in the NPs groups, particularly ZnO-NPs. Milk composition remained unchanged. Gene expression analysis showed significant upregulation of POU1F1, IGF-1, PPARĪ³, CSN2, and FASN in the NPs groups compared to the MPs and control groups, with the highest expression levels observed in the Se-NPs group. These findings suggest that ZnO-NPs and Se-NPs enhance milk production efficiency and upregulate key genes involved in milk yield in Baladi goats.

DOI

10.21608/ejchem.2024.320064.10421

Keywords

Zinc Oxide Nanoparticles, Selenium nanoparticles, milk yield, milk composition, Gene expression, Baladi goats, RT-PCR

Authors

First Name

Hayam

Last Name

Mansour

MiddleName

-

Affiliation

Department of Cell Biology, Biotechnology research institute, National Research Centre, Giza, Egypt.

Email

hayammansour@hotmail.com

City

-

Orcid

0000-0003-2934-4125

First Name

Ahmed

Last Name

Aboamer

MiddleName

A

Affiliation

Dairy science department, National Research center, Dokki, Giza, Egypt

Email

aboamer.nrc@gmail.com

City

-

Orcid

-

First Name

Rania

Last Name

Agamy

MiddleName

-

Affiliation

Animal production department, faculty of agriculture, Cairo university, Egypt

Email

rania.agamy@gmail.com

City

-

Orcid

-

First Name

Shimaa

Last Name

Ali

MiddleName

M

Affiliation

Animal production institute, agriculture research center, NC 12611, Dokki, Giza, Egypt

Email

dr.shimaa8582@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Mohamed

MiddleName

Y

Affiliation

Animal production institute, agriculture research center, NC 12611, Dokki, Giza, Egypt

Email

dr.yassin2005@gmail.com

City

-

Orcid

-

First Name

Mahmoud

Last Name

Abd El-Aziz

MiddleName

E

Affiliation

Polymers and Pigments Department, National Research Centre, Dokki, Giza, , Egypt

Email

mahmoud_essam12@yahoo.com

City

-

Orcid

0000-0001-8816-6571

First Name

Ahmed

Last Name

Darwish

MiddleName

M

Affiliation

Cell Biology Department, Biotechnology Research Institute, National Research Centre, Dokki, Giza, Egypt

Email

adgene@yahoo.com

City

St. Catharines

Orcid

-

First Name

Wagdy

Last Name

Khalil

MiddleName

K.B.

Affiliation

Department of Cell Biology, Biotechnology research institute, National Research Centre, Giza, Egypt.

Email

wagdyph@yahoo.com

City

-

Orcid

-

First Name

Ibrahim

Last Name

Farag

MiddleName

M.

Affiliation

Department of Cell Biology, Biotechnology Research Institute, National Research Centre, Giza, Egypt.

Email

faragim@hotmail.com

City

Dokki

Orcid

-

Volume

68

Article Issue

5

Related Issue

54251

Issue Date

2025-05-01

Receive Date

2024-09-12

Publish Date

2025-05-01

Page Start

445

Page End

454

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 5_Pages 445-454.pdf

PDF . 1.0MB

Link

https://ejchem.journals.ekb.eg/article_391366.html

Detail API

http://journals.ekb.eg?_action=service&article_code=391366

Order

391,366

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Effect Of Zinc Oxide and Selenium Nanoparticles on Milk Production Efficiency and Related Gene Expression in Egyptian Baladi Goats

Details

Type

Article

Created At

29 Mar 2025