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Comparative Study on Cytotoxic Potency, Chemical Composition, and Antioxidant Characteristics of Clove Buds Essential Oil (Syzygium aromaticum) Originating from Indonesia, Comoro

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

Biochemistry

Abstract

To evaluate the anti-tumoral and antioxidant capacities of clove buds essential oils from Indonesia, Comoros Islands and India, we conducted the MTT test, along with various antioxidant capacity assessments, including evaluations of ferrous ions (Fe2+) chelating activity, ammonium molybdate test (TAC), reducing power assay (FRAP), TBARS assay, DPPH, ABTS+ tests, and β-Carotene Bleaching Assay. All examined essential oils displayed significant antioxidant activity in various conducted tests. Moreover, these essential oils have demonstrated strong in vitro cytotoxic effects against two breast cancer cell lines (MDA-MB-468 and MCF-7) and a mouse mastocytoma cell line (P815). Importantly, they have shown the ability to preserve the integrity of healthy cells; specifically peripheral blood mononuclear cells. The chemical composition of the studied essential oils showed that Eugenol, Caryophyllene, and Humulene percentages were notably higher in the Indonesian and Indian samples compared to the Comorian sample. However, the Comorian sample uniquely contained isoeugenol (55.45%), levomenthol (13.39%), eucalyptol (13.30%), and Thymol, which were absent in the Indonesian and Indian samples. The variations in chemical profiles among essential oils from different geographical origins are responsible for the observed differences in antioxidant and cytotoxic activities.

DOI

10.21608/ejchem.2024.300787.9941

Keywords

breast cancer, Chemical composition, Cytotoxicity, essential oil, Syzygium aromaticum, antioxidant capacity

Authors

First Name

Bouchra

Last Name

LOURHLAM

MiddleName

-

Affiliation

Research team on Experimental Oncology; Natural Substances, Cellular Immunopharmacology, Immunology of CancerCells. Faculty of Sciences and Technology, Sultan Moulay Sliman University, Beni Mellal, Morocco

Email

bouchra.lourhlam@usms.ma

City

Beni mellal

Orcid

-

First Name

Abderrazak

Last Name

Idir

MiddleName

-

Affiliation

Research team on Experimental Oncology; Natural Substances, Cellular Immunopharmacology, Immunology of CancerCells. Faculty of Sciences and Technology, Sultan Moulay Sliman University, Beni Mellal, Morocco Science and Technology Team,

Email

a.idir@usms.ma

City

-

Orcid

-

First Name

Maryam

Last Name

Bourhis

MiddleName

-

Affiliation

Research team on Experimental Oncology; Natural Substances, Cellular Immunopharmacology, Immunology of CancerCells. Faculty of Sciences and Technology, Sultan Moulay Sliman University, Beni Mellal, Morocco

Email

maryambourhis@gmail.com

City

-

Orcid

-

First Name

Abdelmajid

Last Name

Zyad

MiddleName

-

Affiliation

Research team on Experimental Oncology; Natural Substances, Cellular Immunopharmacology, Immunology of CancerCells. Faculty of Sciences and Technology, Sultan Moulay Sliman University, Beni Mellal, Morocco

Email

a.zyad@usms.ma

City

-

Orcid

-

First Name

Hassan

Last Name

AIT MOUSE

MiddleName

-

Affiliation

Research team on Experimental Oncology; Natural Substances, Cellular Immunopharmacology, Immunology of CancerCells. Faculty of Sciences and Technology, Sultan Moulay Sliman University, Beni Mellal, Morocco

Email

aitmouse@gmail.com

City

-

Orcid

-

Volume

68

Article Issue

5

Related Issue

54251

Issue Date

2025-05-01

Receive Date

2024-07-03

Publish Date

2025-05-01

Page Start

389

Page End

400

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 5_Pages 389-400.pdf

PDF . 634.1kB

Link

https://ejchem.journals.ekb.eg/article_380006.html

Detail API

http://journals.ekb.eg?_action=service&article_code=380006

Order

380,006

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Comparative Study on Cytotoxic Potency, Chemical Composition, and Antioxidant Characteristics of Clove Buds Essential Oil (Syzygium aromaticum) Originating from Indonesia, Comoro

Details

Type

Article

Created At

29 Mar 2025