The continuous evolution of transportation systems has driven the demand for improved fuel quality and engine performance. Gasoline, as the primary fuel for internal combustion engines, possesses several critical characteristics, including octane rating, volatility, viscosity, and density, which directly influence combustion efficiency and engine behavior. Among these characteristics, the octane rating plays a pivotal role in mitigating engine knocking, a phenomenon caused by premature combustion that leads to inefficiencies, mechanical stress, and increased noise and vibrations. Additionally, volatility affects the fuel's evaporation properties and ignition behavior, while density affects energy content and fuel-air mixing processes. To address these challenges, fuel additives have been extensively utilized to enhance gasoline performance. Octane boosters, detergents, and anti-knock agents improve the fuel's resistance to knocking, optimize combustion, and reduce emissions. These additives not only increase the octane number but also enhance thermal stability, reduce carbon deposits, and minimize wear on engine components. The integration of advanced additive technologies has demonstrated measurable improvements in engine performance, including higher thermal efficiency, reduced vibrations and noise, and extended engine longevity. This review paper illustrated the interplay between gasoline properties and engine performance, emphasizing the role of additives in octane enhancement and their impact on knocking reduction and operational smoothness. Furthermore, the research highlights the significance of optimizing fuel formulations to meet modern transportation demands while addressing environmental sustainability. Through many case studies, this work provides insights into the mechanisms of additive interactions and their contributions to improved fuel efficiency and impact on engine performance.