Abstract Background: Pulmonary tuberculosis is an infectious disease affecting the lungs. It is prevalent in crowded and poorly ventilated areas, posing significant public health challenges. Objective: Evaluate the effect of an educational program outcomes on shifting attitudes and reducing stigma for patients with pulmonary tuberculosis. Methods: Design: Quasi-experimental research design. Sample: Hundered-twenty patients diagnosed with pulmonary TB with age group ranged from 20-65 years from both sex. Setting: The study took place in Al-Badary Central Hospital (chest department) and Assiut Chest Hospital. Tools: A patient assessment sheet and validated questionnaires on attitude and stigma were utilized. Results: Statistical analysis clarified significant improvement in patients` attitude and to positive level stigma post-educational program (p < 0.001). Conclusion: The findings confirmed that educational interventions significantly enhance patients' positive attitudes and reduce tuberculosis-related stigma. Recommendation: It is crucial to incorporate targeted interventions addressing stigma and patient attitudes into tuberculosis management strategies.