This study investigated preventive and ameliorative roles of lactoferrin against LPS induced inflammation in fish common carps. A total of 160 fish were used in this study. Forty common carps were divided equally into 4 groups: control group, control treated with LF group (LF group), LPS group (LPS only) and LPS treated with LF (LPS+LF). The results showed both preventive and protective roles of LF in both LF alone and LPS+LF, respectively. Both preventive and protective role recorded an enhancing effect of LF with a dose of 6g/ kg, which was enough for restoring the liver, blood as well as lipid profiles against LPS (3μg/ ml) induced dysregulation of the bio-vital parameters. In the liver, which is one of the major organs involving in innate and adaptive immunity, a significant change was detected in the ALP, ALT and AST. On the other hand, LF regulated the lipid profile, including cholesterol, triglycerides, LDL and HDL. Additionally, LF was recorded with a significant enhancement and restoration in blood profile including RBCs, WBCs and globulin. Totally, these results suggested the enhancement role of the LF which leads to improvement of the immune- bio-vital status of the body through restoring the liver, lipid and blood profile, suggesting a beneficial and preventive role of lactoferrin as a main source for maintaining and improving industry of the aquatic life in the future.