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418914

New hydrophilic grafting cellulose based on amino-carboxylic acid: Synthesis and antibacterial evaluation

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Last updated: 29 Mar 2025

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Abstract

Background: There is a growing interest in developing the antibacterial properties of hydrophilic polymers. Methods: In this research, new grafting cellulose based on amino-carboxylic acids are obtained and their biological activities are evaluated. The sequences are started by treating cellulose with tosylate chloride to get 2, which further reacts with sodium azide. Results: To produce compound 3. Azide reduction to amino analog by sodium sulfide produces compound 4. The alkylation with chloroacetic acid compound 5 is obtained with amino-acid residue 5. Conclusions: Finally, extensive antibacterial studies have been performed against two types, Staphylococcus aureus and Escherichia coli. The results demonstrated that the novel derivatives may influence bacteria at low concentrations, and their water solubility could lead to them being biocompatible agents.

DOI

10.21608/jbaar.2025.353637.1140

Keywords

antibacterial agents, antimicrobial activity, carbohydrates, Escherichia coli, Staphylococcus aureus

Authors

First Name

Hayder

Last Name

M. Kamal

MiddleName

-

Affiliation

Chemistry Department-Faculty of Science-University of Kufa, Najaf, Iraq

Email

hayderakmala@yahoo.com

City

najaf

Orcid

-

First Name

Asaad

Last Name

H. Aneed

MiddleName

-

Affiliation

Chemistry Department-Faculty of Science-University of Kufa, Najaf, Iraq

Email

asaadneeda@yahoo.com

City

najaf

Orcid

-

First Name

Dhurgham

Last Name

Aziz

MiddleName

-

Affiliation

College of Dentistry, Al-Muthanna University, Samawah 66001, Iraq.

Email

dhurghamziz@gmail.com

City

najaf

Orcid

-

First Name

Nuha

Last Name

S. Kareem

MiddleName

-

Affiliation

Chemistry Department-Faculty of Science-University of Kufa, Najaf, Iraq

Email

nuhaareem4545@yahoo.com

City

najaf

Orcid

-

First Name

Maryam

Last Name

M. Mahdi

MiddleName

-

Affiliation

Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq

Email

maryammahdic@yahoo.com

City

najaf

Orcid

-

First Name

Zahraa

Last Name

H. Hamid

MiddleName

-

Affiliation

ALmustaqbal University, College of Sciences, Department of Biochemistry Sciences

Email

zahraaamidd56@yahoo.com

City

najaf

Orcid

-

Volume

11

Article Issue

1

Related Issue

53815

Issue Date

2025-03-01

Receive Date

2025-01-16

Publish Date

2025-03-01

Page Start

214

Page End

222

Print ISSN

2356-9174

Online ISSN

2356-9182

Article File

JBAAR_Volume 11_Issue 1_Pages 214-222.pdf

PDF . 1.2MB

Link

https://jbaar.journals.ekb.eg/article_418914.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418914

Order

418,914

Type

Original Article

Type Code

1,272

Publication Type

Journal

Publication Title

Journal of Bioscience and Applied Research

Publication Link

https://jbaar.journals.ekb.eg/

MainTitle

New hydrophilic grafting cellulose based on amino-carboxylic acid: Synthesis and antibacterial evaluation

Details

Type

Article

Created At

29 Mar 2025