Aim and objectives; to study the correlation between structural changes by OCT, and functional changes by VEP and PERG in primary open angle glaucoma in order to use these modalities in early diagnosis of primary open angle glaucoma.
Patients and methods; Prospective observational cross-sectional study. The study was held in Mansoura University Ophthalmic Center on sample size of 35 adult patients with open angle glaucoma aiming to study the correlation between three modalities involved in the study, assuming significance level of 0.1%, in a period of one year.
Results; IOP (r= 0.551; p=0.001), C/D ratio (OCT) (r= 0.348; p=0.041), and P50 (ERG) (r= 0.555; p=0.001) are statistically significantly positively correlated with P50 (ERG), VA (r= -0.425; p=0.011) and RNFL thickness (r= -0.501; p=0.002) are statistically significantly negatively correlated with P100 (VEP), while IOP (r= 0.378; p=0.025) is statistically significantly positively correlated with it.
Conclusion;VEP can be used as a noninvasive objective test to detect optic nerve damage at the earlier stage in glaucoma patientss to prevent or delay the progression to irreversible stage.