Background: Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease are interconnected chronic conditions that pose substantial challenges to global public health. Aim of the study: To assess the healthy lifestyle among Type 2 Diabetic patients with non-alcoholic fatty liver. Research design: A descriptive research design was utilized to conduct this study which was conducted in the Diabetic Center at the Main Assiut University hospital. Sample: A simple random sample of 408patients who are followed up in the Diabetic Center. Tools: Interview questionnaire which included personal characteristics, Health-Promoting Lifestyle Profile II questionnaire, Quality of life assessment scale and knowledge about Nonalcoholic fatty liver disease. Result: less than one third (31.4%) of patients were in the 50-60 years age group, 55.6% of them were female, 41.7% of them Class I Obesity. The knowledge mean score was (M= 13.25, SD=5.28), Health Promoting Lifestyle was(M= 146.84, SD=27.06) and Quality of life assessment scale was(M= 82.41, SD= 11.42). Conclusion: The study concludes that there are low knowledge level, Health Promoting Lifestyle was low in physical activity subdomain and low in social domain in Quality of life. There are socio-demographic factors significantly influence patients' knowledge about Nonalcoholic fatty liver disease, adoption of health-promoting lifestyles, and Quality of life. Recommendation: Nursing educational program for patients with Nonalcoholic fatty liver disease should be applied periodically to improve knowledge, promoting health Lifestyle and improving their quality of life.