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419269

Correspondence between Epstein Barr Virus infection and Programmed death ligand 1 in bladder cancer patients

Article

Last updated: 29 Mar 2025

OverviewSimilar Items

Subjects

-

Tags

virology

Abstract

Worldwide, bladder cancer (BC) remains a substantial health challenge, with immune system interactions having an important role in its pathogenesis and progression. Epstein-Barr virus (EBV) has been related to several malignancies, yet its role in BC is not well-understood. Programmed cell death-ligand 1 (PD-L1), an immune checkpoint molecule, has the ability to contribute to tumour immune evasion and has become a major target for immunotherapy. This review explores the potential association between EBV infection, bladder cancer, and the expression of PD-L1. We summarize current evidence on EBV's oncogenic mechanisms, its potential involvement in bladder carcinogenesis, and its influence on PD-L1 regulation. Additionally, we discuss the implications of EBV-associated immune modulation in BC and its potential impact on immunotherapeutic strategies, particularly checkpoint inhibitors. Understanding the interplay between EBV, BC, and PD-L1 may provide new insights into tumour immune escape mechanisms and novel therapies, ultimately improving patient outcomes.

DOI

10.21608/ejmm.2025.369112.1525

Keywords

Epstein Barr Virus, Bladder cancer, Programmed Death Ligand 1

Authors

First Name

Amira

Last Name

Elzalouey

MiddleName

E.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

amiraelzalouey@gmail.com

City

-

Orcid

-

First Name

Sanaa

Last Name

Mohei El-dien

MiddleName

-

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

drsanaamoheyeldien@gmail.com

City

-

Orcid

-

First Name

Sahar

Last Name

Mohamed

MiddleName

T.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University and Horus University, Mansoura, Egypt

Email

sahertaher09@gmail.com

City

Mansoura

Orcid

-

First Name

Doaa

Last Name

Masallat

MiddleName

T.

Affiliation

Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

doaamasallat@yahoo.com

City

-

Orcid

0000-0002-3856-7999

First Name

Ahmed

Last Name

Othman

MiddleName

M.

Affiliation

Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

amosbah64@yahoo.com

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-03-17

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_419269.html

Detail API

http://journals.ekb.eg?_action=service&article_code=419269

Order

419,269

Type

Review articles

Type Code

2,039

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Correspondence between Epstein Barr Virus infection and Programmed death ligand 1 in bladder cancer patients

Details

Type

Article

Created At

29 Mar 2025