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419086

Retrospective Evaluation of the Outcome of Covid-19 Patients Given Pulse Methylprednisolone versus Standard Steroid Therapy

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

virology

Abstract

Background: Except for corticosteroids, no gold standard therapy globally was approved for COVID-19 pneumonia to the date of this study. Studying the pathophysiology of the disease showed that the deterioration that accompany many of cases of COVID-19 pneumonia is related to hyper-immune response causing what is called Cytokine release syndrome/cytokine storm, so, testing various regimens of steroid therapy to control the disease seemed reasonable idea. Objective: To evaluate the results of using different regimens of steroid therapy as a treatment for moderate to severe cases of COVID-19. Methodology: This Study is a retrospective, observational study done on patients with moderate to severe COVID-19 pneumonia who were admitted to the isolation Hospital of Kasr Alainy Medical School, Cairo University, Egypt, between October 2020 and May 2021. Results: In this study we demonstrated statistical difference and increase incidence (ICU stay, need for & length of MV, The incidence of 2ry bacterial infection & GIT bleeding, in hospital mortality) for COVID-19 moderate to severe pneumonia in group A (received pulse steroid therapy) of patients coming during cytokine release syndrome associated COVID-19 pneumonia. Conclusion: Using pulse methyleprednisolone therapy in combination with standard treatment didn't show additional benefit than that could be achieved using standard regimen alone, it lead to multiple side effects regarding increasing hospital mortality, need for mechanical ventilation (either invasive or non- invasive), duration of ICU stay & increase incidence of 2ry bacterial infection and GIT bleeding in patients with moderate to severe COVID-19 pneumonia. Pulsed dose steroid use was more frequent in patients receiving high respiratory support, so future studies should address patient selection and outcome effects of pulsed steroids in severe and deteriorating patients with COVID-19 pneumonia.

DOI

10.21608/ejmm.2025.368957.1526

Keywords

COVID-19, steroid therapy, Pulse Methylprednisolone

Authors

First Name

Ahmed

Last Name

Abdelfattah

MiddleName

N.

Affiliation

Intensive Care, Theodor Bilharz Research Institute, Giza

Email

ahmednasser141290@icloud.com

City

Menoufia

Orcid

-

First Name

Gamal

Last Name

Hamed

MiddleName

-

Affiliation

Critical Care Medicine Department, Faculty of Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Khalid

Last Name

Ibrahim

MiddleName

F.

Affiliation

Critical Care Medicine Department, Faculty of Medicine, Cairo University

Email

-

City

-

Orcid

-

First Name

Mervat

Last Name

Eldmarawy

MiddleName

M.

Affiliation

Intensive Care, Theodor Bilharz Research Institute, Giza

Email

-

City

-

Orcid

-

First Name

Ahmed

Last Name

Abbas

MiddleName

K.

Affiliation

Critical Care Medicine Department, Faculty of Medicine, Cairo University

Email

ahmedabbas@aun.edu.eg

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-03-18

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_419086.html

Detail API

http://journals.ekb.eg?_action=service&article_code=419086

Order

419,086

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Retrospective Evaluation of the Outcome of Covid-19 Patients Given Pulse Methylprednisolone versus Standard Steroid Therapy

Details

Type

Article

Created At

29 Mar 2025