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417827

Impact of Helicobacter pylori Infection on the Onset of Microalbuminuria in Individuals with Type 2 Diabetes Mellitus

Article

Last updated: 29 Mar 2025

OverviewSimilar Items

Subjects

-

Tags

Clinical microbiology

Abstract

Background: Despite the correlation between H. pylori infection and gastrointestinal disorders being extensively established, the primary issue with H. pylori comes from the capacity to induce extra-gastric conditions and its tendency to modify disease phenotypes. Microalbuminuria serves as an early indicator of diabetic nephropathy, a prevalent consequence of diabetes possibly associated with H. pylori infection. Objectives: This study evaluates the correlation between H. pylori infection and microalbuminuria in patients with type 2 diabetes mellitus. Methodology: The case-control study was conducted from August 2024 to December 2024 at the Specialized Hospital for GIT and Liver Surgery Center in (Najaf, Iraq). A total of 180 participants, aged 20 to 75 years, ninety patients with type 2 diabetes mellitus, either with or without H.pylori infection were incorporated alongside 45 individuals exhibiting dyspeptic symptoms without type 2 diabetes, and 45 healthy control volunteers matched for sex and age. All participants have undergone a comprehensive assessment, including a full history and plasma glucose levels, glycated hemoglobin(HbA1c), albumin creatinine ratio (ACR), and H.pylori stool antigen and serum antibodies. Results: There were no significant differences among the study groups T2DM, dyspeptic without type 2 diabetes, and control group in age, weight, height, BMI, Sex, SBP, and DBP (all p>0.05). The comparative results across T2DM subgroups indicate a significant elevation in SBP (p=0.027) and ACR (p=0.001) in the DM-positive H.pylori group relative to the DM-negative H.pylori group. A substantial reduction in body weight (p=0.037) is observed in the DM-positive H.pylori group compared to the DM-negative H.pylori group although there was no significant difference in fasting blood glucose or HbA1c% between the two DM groups. Conclusion: H. pylori infection may significantly facilitate the development of microalbuminuria in individuals with type 2 diabetes.

DOI

10.21608/ejmm.2025.366617.1515

Keywords

Helicobacter pylori, ACR, Microalbuminuria, diabetic nephropathy

Authors

First Name

Ali

Last Name

Nhair Mahood

MiddleName

A.

Affiliation

Department of Pharmaceutical Science, College of Pharmacy, University of Kufa, Iraq

Email

alia.alabadi@student.uokufa.edu.iq

City

-

Orcid

-

First Name

Nibras

Last Name

Abdulsada Al-Ghuraibawi

MiddleName

H.

Affiliation

2Department of Pharmacology, College of Pharmacy, University of Kufa, Iraq

Email

nibrashabdulsada@yahoo.com

City

najaf

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-03-08

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_417827.html

Detail API

http://journals.ekb.eg?_action=service&article_code=417827

Order

417,827

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Impact of Helicobacter pylori Infection on the Onset of Microalbuminuria in Individuals with Type 2 Diabetes Mellitus

Details

Type

Article

Created At

29 Mar 2025