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416752

Association between the RETN Polymorphisms and Breast Cancer Susceptibility

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

Genetics

Abstract

Background: Resistin (RETN), a cysteine-rich adipokine secreted by macrophages or adipose tissue, is expressed via the RETN gene with single nucleotide polymorphisms in 3'-untranslated and RETN promoter locations. Objective: To estimate the relationship between Breast Cancer (BC) in Iraqi patients and RETN single nucleotide polymorphisms. Methodology: A study involving 100 women with BC at Al-Amal Hospital in Iraq analyzed RETN nucleotide polymorphisms from June to October 2023.
Results: Comparison of RETN (rs10401670 T/C) genotypes and alleles between patients with BC and HCs revealed that TC and CC genotypes had significant relations with BC (p< 0.001 and p < 0.001, respectively); the rates of TC and CC genotypes were higher in patients in comparison with HCs, 53 versus 34 and 25 versus 10, respectively, therefore both of them acts as a risk factor with odds ratios of 3.97 (2.06 -7.64) and 6.36 (2.63 -15.40), respectively. The TT genotype was significant protective factor against BC with a ratio of odds: 0.22 (0.12 -0.41) and (p< 0.001); allele analysis revealed that allele T was significant protector with a ratio of odds of 0.35 (0.23 -0.53) and (p<0.001). Conclusion: RETN (rs10401670 T/C) is the only SNP that has a significant impact on cancer risk. Other SNPs, rs3745369 G/C, rs368504053 T/C, and rs74489689 A/G, were not significantly associated with BC.  

DOI

10.21608/ejmm.2025.352588.1440

Keywords

RETN, breast cancer, Resistin

Authors

First Name

Hanan

Last Name

Nayyef

MiddleName

J.

Affiliation

Genetic Engineering and Biotechnology Institute, Baghdad University, Iraq; Tropical Biological Research Unit/College of Science, Baghdad University, Iraq

Email

hanan.nayyef@uobaghdad.edu.iq

City

Baghdad

Orcid

0000-0002-4340-1184

First Name

Ismail

Last Name

Aziz

MiddleName

H.

Affiliation

Genetic Engineering and Biotechnology Institute, Baghdad University, Iraq

Email

ismailh.aziz@ige.uobaghdad.edu.iq

City

-

Orcid

0000-0003-0263-3357

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-02-18

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_416752.html

Detail API

http://journals.ekb.eg?_action=service&article_code=416752

Order

416,752

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Association between the RETN Polymorphisms and Breast Cancer Susceptibility

Details

Type

Article

Created At

29 Mar 2025