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Colistin Resistance Gram-Negative Bacteria as an Emerging Public Health Threat

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

Antimicrobial agents

Abstract

The increasing resistance of multidrug-resistant (MDR) bacteria has become a major threat to public health and has led to the use of polymyxins, with their toxicity, as a last resort in the treatment of infections caused by multidrug-resistant bacterial strains. Currently, two polymyxins are available, polymyxin E (colistin) and polymyxin B. In the mid-1990s, Colistin was introduced as a treatment for infections caused by MDR Gram-negative bacteria (GNB). Unfortunately, resistance to colistin has rapidly emerged after its introduction into treatment protocols against these resistant strains. Considering this, our study focused on the recently discovered mechanisms of colistin resistance, starting from China and then other countries around the world to elucidate the mechanisms of colistin resistance and track the spread of colistin-resistant bacterial strains, which would provide essential information on various aspects of the increasing prevalence of colistin-resistant bacteria. In this context, this review highlights the progress made over the past two decades in understanding the mechanisms of action of colistin and the different strategies used by bacteria to develop colistin resistance, as well as provides an update on what was previously known and what is new, to evaluate the monitoring colistin resistance and identifying resistance trends which deserves further study and development of future strategies to control the spread of multidrug-resistant pathogens.

DOI

10.21608/ejmm.2025.361553.1487

Keywords

Colistin, mcr-genes, multidrug resistance, Gram-negative bacteria, lipid A

Authors

First Name

Hamdi

Last Name

Al-Said

MiddleName

M.

Affiliation

MakkahDepartment of Microbiology and Parasitology, College of Medicine Umm Al Qura University, Makah City, Saudi Arabia

Email

hmibrahim@uqu.edu.sa

City

Makkah

Orcid

0009-0003-2317-9701

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-02-18

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_416455.html

Detail API

http://journals.ekb.eg?_action=service&article_code=416455

Order

416,455

Type

Correspondence articles.

Type Code

2,042

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Colistin Resistance Gram-Negative Bacteria as an Emerging Public Health Threat

Details

Type

Article

Created At

29 Mar 2025