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418783

Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital

Article

Last updated: 29 Mar 2025

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-

Tags

Clinical Research (Medical)

Abstract

Background: Inflammatory and hematological factors that contribute to heart failure (HF) are of increasing interest. Our objective is to determine whether the absolute lymphocyte count (ALC) and the level of severity of HF are correlated among subjects with heart failure with reduced ejection fraction. Methods: 208 suitable individuals having heart failure with reduced ejection fraction (LVEF<50% by echocardiography) were selected for inclusion in the NYHA class—were thoroughly assessed. The neutrophil-to-lymphocyte ratio (NLR) was computed, and complete blood count with automated differential counts was carried out. Results: The Mean Lymphocyte count was 3.6 x1000, 3.4x1000, 1.8x1000, 1.5x1000 in NYHA class I, II, III and IV respectively (P value < 0.001). A significant positive correlation between BNP levels (r = 0.438, p < 0.001), and NYHA class, indicating higher values with increasing NYHA class. Neutrophil-Lymphocyte ratio (NLR) was elevated in participants with NYHA classes I and II more than participants with NYHA classes III and IV (2.9 versus 1.4, P value < 0.001).  Conclusion:Low lymphocytic count and high Neutrophil-Lymphocyte ratio are linked to poor NHYA class and higher BNP levels.

DOI

10.21608/scumj.2025.418783

Keywords

Heart failure, Lymphocyte Count, lymphopenia, NYHA Class

Authors

First Name

Ahmed

Last Name

Sanad

MiddleName

Mohamed

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

drahmedsanad2020@gmail.com

City

-

Orcid

-

First Name

Paula

Last Name

Karam

MiddleName

S

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Eman

Last Name

Mohamed

MiddleName

H.

Affiliation

Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt

Email

-

City

-

Orcid

-

First Name

Fathy

Last Name

Nada

MiddleName

A

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal University, Egypt

Email

fathynada45@hotmail.com

City

-

Orcid

0009-0003-2454-6809

Volume

28

Article Issue

3

Related Issue

53276

Issue Date

2025-03-01

Publish Date

2025-03-01

Page Start

9

Page End

17

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 28_Issue 3_Pages 9-17.pdf

PDF . 281.5kB

Link

https://scumj.journals.ekb.eg/article_418783.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418783

Order

2

Type

Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Relation between the severity of lymphopenia and severi-ty of heart failure in patients with heart failure with re-duced ejection fraction in Suez Canal University Hospital

Details

Type

Article

Created At

29 Mar 2025