Two experiments (pots and field) were performed, during two successive winter seasons (2022/2023 and 2023/2024),  to evaluate the effect of some organic amendments (humic acid (9.53kg/ha) and yeast extract (3g/L) with application rate of (238.1L/ha.)) and Azotobacter bio-fertilizer (2.381L/ha.) on some soil chemical properties and growth and yield of wheat plants under saline conditions. The results indicated that application of treatments especially that contain humic acid led to noticeable increase in the soil organic matter and significantly increased in all plant growth parameters and increased the N, P and K content and uptake by wheat plants. On the other hand, application of these materials led to decrease in soil salinity, soil CaCO3 content and slightly lowering in soil pH. The highest effects on soil properties and plant growth parameters, yield parameters and nutrient content and uptake were obtained by Azotobacter combined with humic acid plus yeast extract. Generally, under saline soil conditions application of combined treatment of humic acid component as organic source (9.53kg/ha.), yeast extract (3g/L) with application rate of (238.1L/ha.)  and Azotobacter bio-fertilizer (2.381L/ha.) which positively affected of soil properties which in turn alleviating the effect of salt stress on plant growth in saline soil and improve and increase growth and yield of wheat plant.