419301

Cardiac Abnormalities in Nonalcoholic Fatty Liver Disease: Echocardiographic and Tissue Doppler Imaging Assessment

Article

Last updated: 29 Mar 2025

Subjects

-

Tags

Internal Medicine.

Abstract

 
Background: Triglycerides cause liver fat buildup. Nonalcoholic Fatty Liver Disease (NAFLD) has a prevalence of  25.24%. Metabolic syndrome connects both NAFLD and heart disease. Imaging aids detection, understanding, and early intervention.
Objectives: To detect cardiovascular abnormalities in NAFLD patients, focusing on the effects of metabolic syndrome on Left ventricle (LV) geometry and function.
Patients and methods: This study is a cross-sectional study from March 2022 to March 2023 involving 100 NAFLD patients (20-60 yrs). Exclusion: age <20 or >60, severe liver disorders, alcoholic fatty liver, hepatitis B/C, active malignancy. Medical history, physical exam, lab (coagulation, liver enzymes, lipid profile, HbA1c, and CBC), radiological (echocardiogram, abdominal ultrasonography, and FibroScan).
Results: The majority had mild NAFLD grade (56%), 38% moderate, and 6% marked. Ejection Fraction positively linked to mild grade, negative to moderate. LSM negatively correlated with mild, positively with marked grades. Body Mass Index is positively related to severely fatty liver. AST, ALT uncorrelated; albumin correlated with grades. LDL positively correlated with mild, negatively with moderate, and marked grades. TG positively correlated with mild, negatively with marked grade; TC negatively with moderate, positively with marked grade. HbA1C negatively correlated with mild, positively with marked grade. Platelet count negatively connected with mild, positively with a moderate grade.
Conclusion: Cardiac motion abnormalities linked to higher fatty liver grades suggest a potential link between NAFLD and cardiac dysfunction . Positive correlations between ejection fraction and mild fatty liver grades suggest protective effects in early-stage NAFLD detection, while negative correlations suggest declining cardiac function with disease progression.

DOI

10.21608/svuijm.2023.229639.1647

Keywords

Cardiac Abnormalities, Echocardiography, FibroSan, Tissue Doppler

Authors

First Name

Fatma Mostafa

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

fatmamostafa202294@gmail.com

City

-

Orcid

-

First Name

Abdelrahman A.

Last Name

Elsaied

MiddleName

-

Affiliation

Department of Clinical Pathology, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

aelsaied@med.svu.edu.eg

City

-

Orcid

-

First Name

Ahlam Mohamed

Last Name

Sabra

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

drahlam.mohamed@med.svu.edu.eg

City

Qena

Orcid

-

First Name

Shimaa Ahmed

Last Name

Abdellah

MiddleName

-

Affiliation

Department of Internal Medicine, Faculty of Medicine, South Valley University, Qena, Egypt.

Email

shimaahaematology@yahoo.com

City

Qena

Orcid

-

Volume

8

Article Issue

1

Related Issue

52988

Issue Date

2025-01-01

Receive Date

2023-08-29

Publish Date

2025-01-01

Page Start

694

Page End

710

Print ISSN

2735-427X

Online ISSN

2636-3402

Link

https://svuijm.journals.ekb.eg/article_419301.html

Detail API

http://journals.ekb.eg?_action=service&article_code=419301

Order

419,301

Type

Original research articles

Type Code

1,520

Publication Type

Journal

Publication Title

SVU-International Journal of Medical Sciences

Publication Link

https://svuijm.journals.ekb.eg/

MainTitle

Cardiac Abnormalities in Nonalcoholic Fatty Liver Disease: Echocardiographic and Tissue Doppler Imaging Assessment

Details

Type

Article

Created At

29 Mar 2025