To minimize use of fish co-product meal (FCPM) in aquafeeds, we assessed the effect of full substitution of FCPM by poultry co-product meal (PCPM) in the  juveniles (initial mean weight: 9.13 ± 3.88g) diet of red hybrid tilapia (RHT) (Oreochromis sp.) for 45 days. Two diets (FCPM ₃₅-PCPM₀ : diet without PCPM and FCPM₀-PCPM₃₅ : diet without FCPM) were formulated using PCPM to replace FCPM protein at 100 % replacement level. After 45 days of exprement, growth performance (GP), nutrient utilization (NU) and integrated zootechnical performance (IZP) indexes of tilapia fed the diet with fishmeal (FCPM₃₅- PCPM₀) showed no significant differences (P < 0.05) compared to tilapia fed with 100% replacement of FCPM with PCPM (FCPM₀-PCPM₃₅). Additionally, FCPM₀- PCPM₃₅ diet induced the reproductive activity indexes (GSI: gonadosomatic index and HIS: hepatosomatic index) significantly better than FCPM₃₅- PCPM₀ diet (P<0.05) in fish. Moreover, the growth of RHT (Oreochromis sp.) is of negative allometric type (b=2.89 and R²=0.94) for FCPM₀-PCPM₃₅ diet and positive allometric (b=3.10 and R²=0.90) for FCPM₃₅-PCPM₀ diet. Furthermore, according to the GP, NU, GSI, HIS and IZP indexes, the PCPM is a good candidate to replace FCPM in diet for juveniles RHT (Oreochromis sp < em>.). Finally, the combination of linear programing technique with GP, NU, GSI, HIS and IZP indexes is therefore a valuable tool that could be useful for sustainable aquaculture.