Background: Cutaneous warts are regarded as the primary manifestation of human papillomavirus (HPV) types. The cell-mediated immune response is believed to be essential for the clearance of HPV. Aim: To study histopathological changes in warts of Egyptian. Patients and Methods: The research involved 25 cases with warts. Histopathologic ally, Skin specimens from lesions have been collected, fixed, sectioned, and stained with H&E for examination under light microscopy and subsequent photography. Results: Biopsies demonstrated variable degrees of papillomatosis, hyperkeratosis, and acanthosis. Also, perinuclear space (koilocyte) and pyknotic nucleus have been discovered. They also showed that most of the patients (56%) have grade 3 hyperkeratosis and parakeratosis while 64% of the patients have grade 2 acanthosis. It also showed that most of the patients (44%) have grade 3 papillomatosis, while 55% of the patients have grade 0 dermal infiltrate. Conclusion: It was concluded that HPV caused mainly the same histopathological changes with different grades.