Background: Validated trauma scoring systems can quickly assess injury severity and indicate prognosis. Several systems have been developed one of which is the modified rapid emergency medicine score (REMS) (2017), which is composed of patient age, and the routinely acquired vital signs systolic blood pressure (SBP), heart rate (HR), respiratory rate (RR), peripheral oxygen saturation, and Glasgow Coma Scale (GCS). Despite most of scores evaluated are used for measuring the severity of the injury and the mortality, less of them are used to predict the use of the emergency intervention and the predicted disposition of the patients. Objective: This study aimed to assess the performance of modified rapid emergency medicine score (mREMS) in predicting the need of emergency interventions and mortality. Patients and methods: This cross-sectional observational study was conducted at Suez Canal University Hospitals in Ismailia and involved 80 adult trauma patients attending to the emergency department. The focus was to appraise the predictive value of mREMS for the need for emergency interventions, emergency surgeries and mortality. Results: mREMS score showed significant positive correlation with tranexamic–acid administration, pelvic binder application, the need for CPR and intubation, while showed no significant correlation with chest tube application. At cutoff value ≥3.5 mREMS score was statistically significant predictor of death, with AUC of 0.873, PPV of 23.5%, NPV of 98.4%, sensitivity of 86% and specificity of 82%. Conclusion: mREMS can predict the need for certain emergency interventions in trauma patients and can predict mortality of the patients at score of more than 3.5.