In the 21^st century, climate change is recognized as one of the most significant global health challenges. Nurses can play a crucial role in reducing the effects of climate change and assisting individuals and communities worldwide to adapt to its impacts. Aim: To evaluate the effect of climate change training programs on staff nurses' knowledge and perceived practice. Research Design: A Quasi-experimental design was utilized. Setting: The study was conducted at Abou El Matamir Central Hospital, El Behera Governorate-Egypt. Sample: A convenient sample of 35 from 68 staff nurses working in the previously mentioned setting. Tools: Staff nurses' knowledge questionnaire regarding climate change and staff nurses' perceived practices regarding climate change. Results: The study found a significant improvement in staff nurses' knowledge regarding climate change across all dimensions post-program, except for the knowledge on reducing its effects (t = 84.58, p = 0.55). There was a significant improvement in perceived practices, except for discussing climate change with patients, and indoor and outdoor daily life practices (t = 31.84, p = 0.39; t = 29.14, p = 0.24; t = 19.73, p = 0.12 respectively). A significant positive correlation was observed between total knowledge and perceived practice post-program (r = 0.787, p = 0.000). Additionally, total knowledge strongly impacted perceived practice (Beta = 0.984, p = 0.00). Conclusion: The study demonstrated significant improvements in staff nurses' knowledge and perceived practices related to climate change post-program, supporting both research hypotheses. Recommendations: Encourage leaders on health care institutions to updates their hospitals policies to include climate change health impact and develop mechanisms for their implementation, application, and follow-up that will affect on sustainability and Egypt vision 2030.