Background: Students with blindness rely on their hands to discover their surroundings, which increases their risk of infection. Consequently, maintaining proper hand hygiene is essential in preventing the spread of those infections. Thus, this study aimed to design innovative health education resources on hand hygiene for Arabic-speaking students with blindness. A phenomenological approach and expert consensus (Delphi method) were employed at Alnour School in Mansoura City; 39 students with blindness were selected conveniently, while 15 experts were purposefully recruited. A tool constructed from six parts, three in simple Arabic, was conveyed with interviews to collect data from students with blindness; the other three parts were self-administered in English to collect data from the expert panelists. Findings reveal that most students with blindness expressed a strong interest in learning about the definition, importance, key times, and steps of hand hygiene. Expert panelists recommended that the designed health education resources (braille-typed booklet, audio booklet, and 3-D maquette) suit all aspects of the physical characteristics of students with blindness. The study concludes that both the students with blindness and expert panelists strongly agreed on all domains of the designed health education resources on hand hygiene. The researchers recommend adopting as well as disseminating the designed innovative health education resources in school libraries and homes nationwide to enhance hand hygiene awareness among students with blindness.