ManageChatDiscover
418566

Interrelation of Urinary Tract Infections and Renal Failure: Evaluating Pathogen Prevalence and the Diagnostic Utility of FGF23 and CFH Biomarkers

Article

Last updated: 09 Apr 2025

OverviewSimilar Items

Subjects

-

Tags

Diagnostics

Abstract

Background: Urinary tract infections (UTIs) are prevalent bacterial infections, particularly among females, often leading to significant morbidity. Renal failure (RF) compromises immune defenses, and increasing susceptibility to infections. Biomarkers such as Fibroblast Growth Factor 23 (FGF23) and Complement Factor H (CFH) have been implicated in renal pathophysiology. Objective: The aim of this work is to investigate the interplay between UTIs and RF by analyzing pathogen prevalence and assessing FGF23 and CFH levels in affected patients. Methodology: A cross-sectional study was conducted involving patients diagnosed with UTI and/or RF. Midstream urine samples were collected for microbiological analysis using the VITEKĀ® 2 Compact system. Serum levels of FGF23 and CFH were measured using enzyme-linked immunosorbent assay, respectively. Data were analyzed to identify associations between pathogen prevalence, biomarker levels, and patient demographics. Results. The study revealed a higher incidence of UTIs among younger females. Escherichia coli was identified as the predominant uropathogen. Patients with RF exhibited significantly elevated levels of FGF23 and CFH compared to those without RF. These biomarkers demonstrated high predictive accuracy for renal impairment. Conclusion: The findings highlight the importance of monitoring FGF23 and CFH levels in patients with renal impairment. Early detection of elevated levels can facilitate timely interventions to mitigate progression and manage complications. Understanding demographic predispositions to UTIs can inform targeted prevention strategies, particularly among younger females, to reduce infection rates and associated renal complications.

DOI

10.21608/ejmm.2025.368537.1523

Keywords

Urinary tract infection, renal failure, FGF23, CFH, biomarkers

Authors

First Name

Ahmed

Last Name

Alkarewy

MiddleName

H.K.

Affiliation

Department of Medical Microbiology, College of Medicine, University of Kerbala, Kerbala, Iraq

Email

ahmed.hassen@s.uokerbala.edu.iq

City

-

Orcid

-

First Name

Ali

Last Name

Alyassery

MiddleName

J.A

Affiliation

Department of Medical Microbiology, College of Medicine, University of Kerbala, Kerbala, Iraq

Email

ali.jalel@uokerbala.edu.iq

City

-

Orcid

0000-0001-9244-9881

First Name

Masar

Last Name

Al-Mousawi

MiddleName

R.R.

Affiliation

Department of Medical Microbiology, College of Medicine, University of Kerbala, Kerbala, Iraq

Email

masar.almousawi@uokerbala.edu.iq

City

-

Orcid

0000-0002-5485-3485

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-03-15

Publish Date

2025-04-01

Page Start

301

Page End

407

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 2_Pages 301-407.pdf

PDF . 5.4MB

Link

https://ejmm.journals.ekb.eg/article_418566.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418566

Order

418,566

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Interrelation of Urinary Tract Infections and Renal Failure: Evaluating Pathogen Prevalence and the Diagnostic Utility of FGF23 and CFH Biomarkers

Details

Type

Article

Created At

29 Mar 2025