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418804

Baicalein mitigates Indomethacin-Induced Gastric Ulcer in Rats: Involvement of the PI3K/Akt/NF-kB pathway

Article

Last updated: 29 Mar 2025

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-

Tags

Renal Physiology

Abstract

Background: Peptic ulcer is a major health concern. Compared to other NSAIDs, indomethacin (IND) typically has a higher ulcerogenic potential. As a flavonoid, baicalein (Baic) has anti-inflammatory and antioxidant qualities.
Objective: to evaluate the gastroprotective impact of Baic on stomach ulcers caused by IND and to identify any possible underlying processes.
Material and Methods: Thirty male rats were split into three: control, Ulcer, Ulcer+ Baic (10/group). Gastric ulcer index values, gastric PH, gastric PGE2, gastric MDA, gastric SOD, gastric TNF-α, gastric IL-1β, and gastric genes expression of NF-kB, PI3K, and Akt were evaluated. In addition to histolopathological and COX2 immunohistochemical evaluation of gastric tissue were performed.
Results: The Ulcer group showed substantially higher gastric ulcer index values, gastric MDA, gastric TNF-α, gastric IL-1β, and gastric gene expression of NF-kB and gastric COX2 immunoreaction with dramatically decline in gastric PH values, gastric SOD, gastric PGE2 and gastric genes expression of PI3K and Akt compared to the control. Baic dramatically improved IND-induced changes in gastric tissue.
Conclusion: Baic has gastroprotective benefits in rats with IND-induced ulcers via modifying the Akt/Pi3k/NF-kB signaling pathway and by having anti-inflammatory and antioxidant qualities.

DOI

10.21608/besps.2025.349392.1196

Keywords

Akt Baicalein, COX2 Gastric Ulcer, Indomethacin, NF-kB, PI3K

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical physiology department, faculty of Medicine, Menoufia University

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Amany

Last Name

Wahb

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Helwan University, Egypt

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

Mostafa

Last Name

Arafa

MiddleName

Makram

Affiliation

Internal Medicine Department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

rose_a.hashem256@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Shahien

MiddleName

Awad

Affiliation

Clinical Pharmacology Department, Faculty of medicine, Damitta University, Egypt

Email

moh_shahien@du.edu.eg

City

-

Orcid

-

First Name

Marwa

Last Name

Safwat

MiddleName

Mohamed

Affiliation

Human Anatomy and Embryology Department, Faculty of Medicine, Ain Shams University, Ain Shams, Cairo, Egypt Anatomy Department, IbnSina National College for Medical Studies, Jeddah.

Email

soso_egy86@yahoo.com

City

-

Orcid

-

First Name

Radwa

Last Name

Ali

MiddleName

Hassan

Affiliation

Medical Physiology Department, Faculty of Medicine, Ain Shams University,Cairo Egypt Faculty of Medicine, Armed Forces College of Medicine (AFCM), Cairo, Egypt

Email

dr.radwahassan@med.asu.edu.eg

City

-

Orcid

0000-0002-7877-2698

First Name

Kariman

Last Name

Abdel Wahab

MiddleName

Kariman Hussein

Affiliation

Pathology Department, Faculty of Medicine, Helwan University, Egypt.

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Shawky

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Helwan University, Egypt

Email

noha.osama@med.helwan.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

50792

Issue Date

2025-04-01

Receive Date

2025-01-02

Publish Date

2025-04-01

Page Start

269

Page End

281

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 45_Issue 2_Pages 269-281.pdf

PDF . 876.8kB

Link

https://besps.journals.ekb.eg/article_418804.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418804

Order

418,804

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Baicalein mitigates Indomethacin-Induced Gastric Ulcer in Rats: Involvement of the PI3K/Akt/NF-kB pathway

Details

Type

Article

Created At

29 Mar 2025