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418802

Metrnl impact in streptozotocin induced diabetic nephropathy in rats, targeting Nrf2/HO-1 pathway

Article

Last updated: 29 Mar 2025

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-

Tags

Renal Physiology

Abstract

Introduction: The most prevalent complications in diabetes mellitus is diabetic nephropathy (DN). Metrnl's role in endocrine metabolism has been well investigated. It has been demonstrated to contribute to the healing of inflammatory injury.Objective: to assess the potential underlying processes and the protective impact of Metrnl in DN caused by STZ
Materials and Methods: Thirty adult male albino rats were split into: control, DN, and DN+Metrnl (10/group). Urine albumin, serum glucose, serum glycosylated Hb A1c, serum urea, serum creatinine, serum cystatin C, creatinine clearance, renal MDA, renal GSH, renal TNF-α, renal IL-10, and renal gene expression of HO-1 and Nrf2 were assessed. Additionally, immunohistochemical and renal histopathology studies were carried out.Results The DN group had significantly higher serum levels of glucose, glycosylated Hb A1c, urea, creatinine, cystatin C, urinary albumin, renal MDA, and renal TNF-α than the control group, but they also had significantly lower renal GSH, renal IL-10, creatinine clearance values, and Nrf2 and HO-1 gene expression. Furthermore, NF-kB and Bax immunoreaction were upregulated in the DN compared to control. The STZ-induced DN alterations significantly improved in the DN+Metrnl group.Conclusion: Metrnl offers substantial protection against STZ-induced DN through anti-oxidant and anti-inflammatory pathways, apoptosis inhibition, and the up-regulation of Nrf2 and HO-1 renal gene expressions.

DOI

10.21608/besps.2025.349279.1195

Keywords

Bax Diabetic Nephropathy, HO-1 Metrnl, NF-kB Nrf2

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical physiology department, faculty of Medicine, Menoufia University

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Amany

Last Name

Wahb

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Helwan University, Egypt

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Ibrahim

MiddleName

Ali

Affiliation

Internal Medicine Department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

rose_a.hashem256@yahoo.com

City

-

Orcid

-

First Name

Amany

Last Name

Elfakhrany

MiddleName

-

Affiliation

Clinical Pharmacology Department, Faculty of medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

amany.elfakhrany@med.menofia.edu.eg

City

-

Orcid

-

First Name

Haitham

Last Name

Sewilam

MiddleName

M.

Affiliation

Department of Histology, Faculty of Medicine, Helwan University, Helwan, Egypt

Email

haitham.sewilam@gmail.com

City

-

Orcid

-

First Name

Noha

Last Name

Shawky

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Helwan University, Egypt

Email

noha.osama@med.helwan.edu.eg

City

-

Orcid

-

First Name

Shaimaa

Last Name

Dawa

MiddleName

K

Affiliation

Pathology Department - Faculty of Medicine, Banha University, Egypt

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

Radwa

Last Name

Ali

MiddleName

Hassan

Affiliation

Medical Physiology Department, Faculty of Medicine, Ain Shams University,Cairo Egypt Faculty of Medicine, Armed Forces College of Medicine (AFCM), Cairo, Egypt

Email

dr.radwahassan@med.asu.edu.eg

City

-

Orcid

0000-0002-7877-2698

Volume

45

Article Issue

2

Related Issue

50792

Issue Date

2025-04-01

Receive Date

2025-01-02

Publish Date

2025-04-01

Page Start

258

Page End

268

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 45_Issue 2_Pages 258-268.pdf

PDF . 733.4kB

Link

https://besps.journals.ekb.eg/article_418802.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418802

Order

418,802

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Metrnl impact in streptozotocin induced diabetic nephropathy in rats, targeting Nrf2/HO-1 pathway

Details

Type

Article

Created At

29 Mar 2025