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Maresin-1 mitigates streptozotocin induced diabetic nephropathy in rats via up-regulation of Nrf2/HO-1 pathway

Article

Last updated: 29 Mar 2025

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-

Tags

Renal Physiology

Abstract

Introduction: One serious health issue is diabetic nephropathy (DN). A lipid mediator that is naturally produced from omega-3 fatty acids, maresin-1 (MaR1), may be able to considerably lessen the symptoms of a number of inflammatory illnesses.
Objective: to assess the potential underlying processes and the protective impact of Maresin-1 in DN caused by STZ
Materials and Methods: Thirty adult male albino rats were divided into: control, DN group, and DN+MaR1 group (10/group). levels of urine albumin, renal SOD, creatinine clearance, renal MDA, renal TNF-α, renal IL-6, and renal genes expression of nuclear factor E2-related factor 2 (Nrf2) and heme-oxygenase 1 (HO-1) in addition to serum levels of glucose, glycosylated Hb A1c, urea, and creatinine. Furthermore, renal histopathology and immunohistochemical analyses were performed.
Results Along with urinary albumin, renal MDA, renal TNF-α, and renal IL-6, DN significantly increased serum levels of glucose, glycosylated Hb A1c, urea, and creatinine when compared to the control. Additionally, it dramatically reduced the expression of the renal genes Nrf2 and HO-1, renal SOD, and creatinine clearance levels. In addition, the DN group's NF-kB immunoreaction and Caspase-3 were both upregulated in comparison to the control. The DN+MaR1 group showed a considerable improvement in STZ-induced DN changes.
Conclusion: Through anti-oxidant and anti-inflammatory mechanisms, apoptosis suppression, and the up-regulation of Nrf2 and HO-1 renal gene expressions, MaR1 provides significant protective benefits against STZ-induced DN.

DOI

10.21608/besps.2025.347094.1193

Keywords

diabetic nephropathy, HO-1, Maresin-1, NF-kB, Nrf2

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical physiology department, faculty of Medicine, Menoufia University

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Dina

Last Name

Elzeiny

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Mansoura University, Egypt. Medical Biochemistry and Molecular Biology Department, Faculty of medicine, New Mansoura University, Egypt.

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

rose_a.hashem256@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Elmetwally

MiddleName

Abdel-monem

Affiliation

Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt. 35516

Email

drahmad.salman82@gmail.com

City

-

Orcid

-

First Name

Sara

Last Name

Mowafy

MiddleName

Mohamed

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Portsaid University, Portsaid, Egypt

Email

sarah.mohamed@med.psu.edu.eg

City

-

Orcid

-

First Name

Sarah

Last Name

Abo EL-Soud

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt.

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Kamal

MiddleName

-

Affiliation

Internal Medicine and Nephrology department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt.

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Shorouk

Last Name

Elmorshdy

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

shoroukelsaeed@mans.edu.eg

City

-

Orcid

-

First Name

Rania

Last Name

Mansour

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Email

soso_89@yahoo.com

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

50792

Issue Date

2025-04-01

Receive Date

2024-12-23

Publish Date

2025-04-01

Page Start

246

Page End

257

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 45_Issue 2_Pages 246-257.pdf

PDF . 800.6kB

Link

https://besps.journals.ekb.eg/article_418800.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418800

Order

418,800

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Maresin-1 mitigates streptozotocin induced diabetic nephropathy in rats via up-regulation of Nrf2/HO-1 pathway

Details

Type

Article

Created At

29 Mar 2025