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Albiflorin mitigates Renal Impairment in Hyperuricemic Rats by modulating HMGB1/TLR4/NF-kB signaling pathway

Article

Last updated: 29 Mar 2025

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Tags

Renal Physiology

Abstract

Background: It is becoming more well accepted that hyperuricemia may be a contributing factor to hypertension, renal illness, and a number of detrimental effects of vascular disease. It has been shown that albiflorin (ALB) has potent pharmacological effects in preventing oxidation, inflammation, and apoptosis.
Objective: to illustrate the underlying mechanisms and renoprotective impact of ALB in hyperuricemic rats.
Material & Methods: Thirty Wister albino male rats divided into control, HU, HU+ALB groups. After 8 weeks rats were subjected to arterial blood pressure (ABP), renal blood flow velocity (RBFV) and renal artery resistance (RAR) measurement and serum levels of urea, creatinine in addition to creatinine clearance, urinary protein, renal MDA, SOD, TNF-α, IL-6, renal genes expression of HMGB1, TLR4 and NF κB were assessed. Renal tissue was evaluated histopathologically and immunohistochemically.
Results: The measured SBP, DBP , MABP, RAR, serum levels of uric acid, urea, creatinine in addition to urinary protein, renal MDA, renal TNF-α, renal IL-6, renal genes HMGB1, TLR4 and NF-kB of HU group were dramatically increased compared to control however RBFV, renal SOD and creatinine clearance values of HU group were substantially decreased compared to control. In addition there were dramatically upregulated Bax and NF-kB immunoreaction of HU group compared to control. ALB significantly enhanced the alterations brought about by HU.
Conclusion: Through anti-oxidant, anti-inflammatory, and anti-apoptotic processes as well as the down-regulation of HMGB1, TLR4, and NF κB renal gene expression, ALB reduced HU-induced renal impairment

DOI

10.21608/besps.2025.347056.1192

Keywords

Albiflorin Bax, HMGB1 Hyperuricemia, NF κB TLR4

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Medical physiology department, faculty of Medicine, Menoufia University

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

-

Orcid

0000-0002-2535-9445

First Name

Noha

Last Name

Bayomy

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

Karema

Last Name

Diab

MiddleName

Abdelhady

Affiliation

Clinical Pathology Department, National Liver Inistitute, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

karemadiab6@yahoo.com

City

-

Orcid

-

First Name

Noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

4Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt

Email

hashem877@yahoo.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Shahien

MiddleName

Awad

Affiliation

Clinical Pharmacology Department, Faculty of medicine, Damitta University, Egypt

Email

moh_shahien@du.edu.eg

City

-

Orcid

-

First Name

Sara

Last Name

Mowafy

MiddleName

Mohamed

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Portsaid University, Portsaid, Egypt

Email

sarah.mohamed@med.psu.edu.eg

City

-

Orcid

-

First Name

Sara

Last Name

Abo EL-Soud

MiddleName

-

Affiliation

Pathology Department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt.

Email

rose_a.hashem256@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Kamal

MiddleName

-

Affiliation

Internal Medicine and Nephrology department, Faculty of Medicine, Menoufia University Shebin El-Kom, Menoufia, Egypt.

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

Samar

Last Name

Hussein

MiddleName

M

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

samarhussein@med.suez.edu.eg

City

-

Orcid

-

First Name

Shorouk

Last Name

Elmorshdy

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

shoroukelsaeed@mans.edu.eg

City

-

Orcid

-

Volume

45

Article Issue

2

Related Issue

50792

Issue Date

2025-04-01

Receive Date

2024-12-23

Publish Date

2025-04-01

Page Start

232

Page End

245

Print ISSN

1110-0842

Online ISSN

2356-9514

Article File

BESPS_Volume 45_Issue 2_Pages 232-245.pdf

PDF . 854.7kB

Link

https://besps.journals.ekb.eg/article_418799.html

Detail API

http://journals.ekb.eg?_action=service&article_code=418799

Order

418,799

Type

Original Article

Type Code

567

Publication Type

Journal

Publication Title

Bulletin of Egyptian Society for Physiological Sciences

Publication Link

https://besps.journals.ekb.eg/

MainTitle

Albiflorin mitigates Renal Impairment in Hyperuricemic Rats by modulating HMGB1/TLR4/NF-kB signaling pathway

Details

Type

Article

Created At

29 Mar 2025