Artificial intelligence provides visually impaired adolescent females with a more inclusive and efficient method of learning procedures about breast self-examination, ensuring that they can identify and detect breast abnormalities early. The study aims to investigate the effect of artificial intelligence using the Be My Eyes app on knowledge and practice regarding breast self-examination among female adolescents with visual impairments. Design: A quasi-experimental design (pre/post-test) was utilized. Setting: The study was conducted at Al Noor School for visually impaired students in Shebein El-kom City, Menoufia Governorate. Sample: A purposive sample of 50 visually impaired female adolescents. Tools: Three tools were used to collect the data of the study: a structured interviewing questionnaire, a knowledge and practice assessment tool regarding breast self-examination through the Be My Eyes app, and an observational checklist of female adolescent practice. Results: The findings revealed a highly statistically significant difference in visually impaired females' adolescent total knowledge and practice scores for breast self-examination before and after using the Be My Eyes application. The adolescent female's total knowledge and practice improved in the posttest and follow-up compared to the pretest. Conclusion: Adolescent females with visual disabilities saw improvements in their BSE knowledge and practices as a result of using AI, also making health education more accessible. AI empowers adolescent females with visual disabilities to take control of their health in a way that was previously challenging due to their visual impairments. Recommendations: Future research should explore the development of more advanced AI systems that can be further personalized to suit the unique needs of adolescent females with varying levels of visual impairment.