Aim: The present study investigates the effect of acid-resistant adhesive system with preceding sandblasting or silane addition on the shear bond strength (SBS) of indirect hybrid blocks. Materials and methods: Forty-five extracted sound human molars were embedded in a rectangular transparent acrylic resin block. Ninety indirect hybrid ceramic discs were obtained by milling the blocks, sectioned into (4mm x 4mm x 1mm) discs, and polished. The discs were randomly divided into six groups -15 specimens each- based on the adhesive agent and surface treatment. BeautiBond Xtreme was applied to groups 1, 3 and 5, and Futurabond was applied to groups 2, 4 and 6.  Groups 1, 2, 3 and 4 were treated with 9% hydrofluoric acid. Groups 1 and 2 did not receive a separate silane coupling agent, whereas groups 3 and 4 had a layer of silane coupling agent applied before the bonding agent. Sandblasting was carried out for groups 5 and 6. The SBS test and failure mode analysis was performed for the 6 groups to identify the adhesion quality between the luting cement and the hybrid discs. One-way ANOVA test was used to compare mean values followed by the post-hoc Tukey test to compare between the different groups. Results:  Group 6 stands out with the highest mean of 15.3784 MPa, followed by Group 5 at 12.3524 MPa. In contrast, Group 4 shows the lowest mean at 8.23962 MPa. Conclusion: This initial comparison suggests that surface treatments using Sandblasting significantly impact shear bond strength.