Background: The body's greatest organ is the epidermis. This is the initial defense against the external environment.
Objective: This study aimed to investigate the possible effect of jojoba nano-emulsion with or without vitamin D on experimentally-induced cutaneous lesion in adult male albino rats. 
Materials and methods: A strain of 28 adult male albino rats was employed. Their body weight ranged between 130-100 g. They were left 2 weeks for accommodation to environment of the laboratory in Al-Azhar Medical Physiology Department. The rats were separated randomly into 4 equal groups as follows: Group I [control group], Group II [vitamin D-treated group], Group III [jojoba nano-emulsion-treated group], Group IV [vitamin D and jojoba nano-emulsion-treated group].
Results:  There were significant variances in IL-10 levels among groups, with G2 having non-significant higher levels than G1, G3 and G4 having higher levels than G1, and G3 having higher levels than G2. Vitamin D plus Fucidin did not significantly increase IL-10 compared to Fucidin alone, but jojoba alone or with vitamin D increased IL-10 levels. Vitamin D plus Fucidin led to a mild decrease in TNF-α, but jojoba significantly reduced it.
Conclusion: The current study showed that jojoba nano-emulsion either with or without vitamin D were promising on cutaneous lesions healing, but jojoba nano-emulsion with vitamin D showed the most promising results. The combination of jojoba nano-emulsion and vitamin D treatment had a potent anti-inflammatory effect. This was demonstrated by the low levels of pro-inflammatory mediators. The combined treatment also showed superior antioxidant capacity.