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Evaluating the Antiviral and Antimicrobial Potentials of Chenopodium murale Extracts: Exploring Natural Solutions for Health and Medical Applications

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Last updated: 29 Mar 2025

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Tags

Pharmaceutical Chemistry

Abstract

Background: Chenopodium murale (C. murale), a plant used in herbal medicine, is rich in essential oils and bioactive compounds. Given the urgent need for natural sanitisers and disinfectants, this study aimed to evaluate the antiviral and antimicrobial properties of various C. murale extracts and to develop an adequate, low-toxicity, ready-to-use green preparation.
Methods: Crude extracts of C. murale prepared with ethanol, methanol, acetone, ethyl acetate, and hexane were tested for cytotoxicity, antiviral, and antimicrobial activities. Liquid Chromatography/Mass Spectrometry was used to identify the metabolites in the most potent extract.
Results: The ethanol extract of C. murale showed promising antiviral activity, particularly against adenovirus type 7, without significant toxicity to tested cell lines. Identified compounds in the crude ethanolic extract included pentoses, hexoses, amino acids, flavonoids, carotenoids, terpenoids, sterols, and glycosides. The essential oil derived from C. murale, containing p-cymene and a-terpinene, demonstrated antimicrobial properties. Combined with other essential oils, the plant extracts showed activity against various microbial species, aligning with previous research on the antimicrobial effects of C. murale.
Conclusion: This study highlights the potential of C. murale and its ethanolic extract as a potent natural antiviral source for various health and medical applications.

DOI

10.21608/ejchem.2024.293838.9789

Keywords

Antimicrobial, Antiviral, Chenopodium murale, Coronavirus, Cytotoxicity, Metabolite profiling

Authors

First Name

Gihan

Last Name

Zaghlol

MiddleName

-

Affiliation

Department of Botany and Microbiology, Faculty of science, Helwan University, Ain Helwan, Cairo, Egypt.

Email

gihan.zaghlol@science.helwan.edu.eg

City

-

Orcid

-

First Name

Mohsen

Last Name

Sayed

MiddleName

-

Affiliation

Botany and Microbiology Department, Faculty of Science, Cairo University,12613, Egypt.

Email

mohsenab2005@yahoo.com

City

Giza

Orcid

0000-0002-2305-9043

First Name

Sayed

Last Name

Abo El-Souad

MiddleName

-

Affiliation

Faculty of Science, Cairo University

Email

msayed@sci.cu.edu.eg

City

-

Orcid

-

First Name

Amena

Last Name

El-Feky

MiddleName

S.

Affiliation

Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt.

Email

amenasayed75@gmail.com

City

-

Orcid

-

First Name

Sohaila

Last Name

Awad

MiddleName

S.

Affiliation

Chemistry and Biochemistry Department, Faculty of Science, Cairo University, Cairo, Egypt

Email

sohailasabryawad@gmail.com

City

-

Orcid

-

First Name

Fatma

Last Name

Elfiky

MiddleName

R.

Affiliation

Biophysics Department, Faculty of Science, Cairo University, Cairo, Egypt.

Email

fatmaelfiky20@gmail.com

City

-

Orcid

-

First Name

Maram

Last Name

Abdelghany

MiddleName

A.

Affiliation

Biotechnology Department, Faculty of Science, Cairo University, Cairo, Egypt.

Email

maraamadeel@gmail.com

City

-

Orcid

-

First Name

hanaa

Last Name

elmalla

MiddleName

-

Affiliation

Chemistry and Zoology Department, Faculty of Science, Cairo University, Cairo, Egypt

Email

hanaaelmalla15@gmail.com

City

-

Orcid

-

First Name

Heba M.

Last Name

Fahmy

MiddleName

-

Affiliation

Biophysics Department, Faculty of Science, Cairo University, 12613, Egypt.

Email

hfahmy@sci.cu.edu.eg

City

-

Orcid

-

Volume

68

Article Issue

5

Related Issue

54251

Issue Date

2025-05-01

Receive Date

2024-06-15

Publish Date

2025-05-01

Page Start

149

Page End

165

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 5_Pages 149-165.pdf

PDF . 3.5MB

Link

https://ejchem.journals.ekb.eg/article_380005.html

Detail API

http://journals.ekb.eg?_action=service&article_code=380005

Order

380,005

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Evaluating the Antiviral and Antimicrobial Potentials of Chenopodium murale Extracts: Exploring Natural Solutions for Health and Medical Applications

Details

Type

Article

Created At

09 Mar 2025