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382797

Impact of Some miRNAs Expression on Induction of Obesity Related Diseases

Article

Last updated: 09 Mar 2025

OverviewSimilar Items

Subjects

-

Tags

Biochemistry

Abstract

Background: Obesity is a concerning health problem globally. Previous studies demonstrated the role of miR-15a and miRNA Let-7 in adipocyte development and in regulation of glucose metabolism.

Methods and results: Blood samples of 65 obese patients (17 obese hypertensive patients, 24 obese diabetic patients, and 24 obese without complications) and 45 healthy volunteers were used as control: fasting blood glucose, fasting insulin, lipid profile and HOMA-IR as well as miRNA-15a and miRNA Let-7 expression levels.

All tested biochemical parameters were significantly increased in all obese groups compared with the controls. The expression of miRNA 15a was significantly decreased in all obese groups in comparison with the controls especially the obese diabetic group, while the expression of miRNA Let-7 showed no significant difference between the studied groups with only a significant increase in obese hypertensive group.

Conclusions: MiR15a level was reduced in the obese diabetic group, this finding highlights the role of miR15a in diabetes development. MiRNA Let-7 expression was decreased in diabetic obese patients while increased in hypertensive obese, suggesting its value in progression of diabetes and hypertension as obesity complications.

DOI

10.21608/ejchem.2024.307399.10085

Keywords

Keywords: Obesity, diabetes, Hypertension, miRNA-15a, miRNA Let-7

Authors

First Name

Mai

Last Name

Nabawy

MiddleName

-

Affiliation

Department of Biotechnology and Life Science, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Egypt.

Email

mainabawy10@gmail.com

City

-

Orcid

-

First Name

Weaam

Last Name

Gouda

MiddleName

-

Affiliation

Biochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.

Email

weaam_gouda@yahoo.com

City

Giza

Orcid

0000-0002-5571-142X

First Name

Hatim

Last Name

El-Baz

MiddleName

A.

Affiliation

Biochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.

Email

helbaz78@yahoo.com

City

Dokki, Giza

Orcid

0000-0003-3156-7870

First Name

Mie

Last Name

Afify

MiddleName

-

Affiliation

Biochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.

Email

mieafify@yahoo.com

City

-

Orcid

0000-0002-3187-1322

First Name

Waleed

Last Name

Hamimy

MiddleName

I

Affiliation

Department of Anesthesia, Surgical ICU and Pain Management, Faculty of Medicine, Cairo University, Cairo, Egypt.

Email

walid.hamimy@kasralainy.edu.eg

City

Giza

Orcid

0000-0003-4654-011X

First Name

Mohamed D. E.

Last Name

Abdelmaksoud

MiddleName

-

Affiliation

Biochemistry Department, Biotechnology Research Institute, National Research Centre, Giza, Egypt.

Email

dr_mohameddiaa1965@yahoo.com

City

Giza

Orcid

0000-0002-9312-0807

First Name

Amr E.

Last Name

Ahmed

MiddleName

-

Affiliation

Department of Biotechnology and Life Science, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Egypt.

Email

amreahmed@hotmail.com

City

-

Orcid

0000-0003-0628-4422

First Name

Walaa G.

Last Name

Hozayen

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Science, Beni-Suef University

Email

walaahozayen@hotmail.com

City

-

Orcid

-

Volume

68

Article Issue

5

Related Issue

54251

Issue Date

2025-05-01

Receive Date

2024-07-27

Publish Date

2025-05-01

Page Start

77

Page End

83

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 5_Pages 77-83.pdf

PDF . 477.4kB

Link

https://ejchem.journals.ekb.eg/article_382797.html

Detail API

http://journals.ekb.eg?_action=service&article_code=382797

Order

382,797

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Impact of Some miRNAs Expression on Induction of Obesity Related Diseases

Details

Type

Article

Created At

09 Mar 2025