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347180

Protective Effects of Cinnamic Acid Against Monosodium Glutamate Toxicity in Rats

Article

Last updated: 09 Mar 2025

Subjects

-

Tags

Chemistry

Abstract

Abstract

Background: Monosodium glutamate (MSG), a common food additive, has demonstrated potential organotoxic effects in animal studies. Cinnamic acid (CA), a naturally occurring phenylpropanoic acid, is known for its antioxidant and anti-inflammatory properties.

Objective: This research aimed to evaluate the protective role of CA against MSG-induced toxicity in rat models.

Methods: The study utilized twenty-five male albino rats, divided into five groups (n=5 each). The groups were: I - control (basal diet); II - MSG oral administration (3.0 g/kg body weight); III - MSG oral administration with CA (40 mg/kg body weight); IV - MSG via intraperitoneal injection (4 mg/kg body weight); V - MSG intraperitoneal injection with CA (40 mg/kg body weight). Post-treatment, serum was analyzed for biochemical changes.

Results: CA administration significantly reduced blood glucose and leptin levels while elevating insulin levels in MSG-treated rats. Furthermore, CA markedly reduced malondialdehyde (MDA) levels and increased superoxide dismutase (SOD) and glutathione (GSH) levels, indicating a reduction in oxidative stress.

Conclusion: The study reveals CA's capability in ameliorating MSG-induced metabolic alterations and oxidative stress, underscoring its potential as a therapeutic agent in managing biochemical disturbances related to MSG exposure.

DOI

10.21608/aels.2024.266825.1046

Keywords

cinnamic acid, Monosodium glutamate (MSG), Oxidative Stress, Anti-oxidant, Lipid profile

Authors

First Name

Mona

Last Name

Hamza Abd El-Aziz

MiddleName

Mohammed

Affiliation

Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

Email

mkandeel151617@gmail.com

City

awseem

Orcid

29012232102869

First Name

Ohoud

Last Name

Marie

MiddleName

Mohamed

Affiliation

Chemistry Department, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt

Email

ohoud@science.suez.edu.eg

City

-

Orcid

0000-0003-2846-8476

First Name

amina

Last Name

Dessouki

MiddleName

ali

Affiliation

Pathology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

aminadessouki@vet.suez.edu.eg

City

ismallia

Orcid

-

Volume

5

Article Issue

2

Related Issue

54223

Issue Date

2024-03-01

Receive Date

2024-02-07

Publish Date

2024-03-01

Page Start

34

Page End

46

Print ISSN

2805-3060

Online ISSN

2805-3079

Link

https://aels.journals.ekb.eg/article_347180.html

Detail API

http://journals.ekb.eg?_action=service&article_code=347180

Order

3

Type

Original research articles

Type Code

2,116

Publication Type

Journal

Publication Title

Advances in Environmental and Life Sciences

Publication Link

https://aels.journals.ekb.eg/

MainTitle

Protective Effects of Cinnamic Acid Against Monosodium Glutamate Toxicity in Rats

Details

Type

Article

Created At

09 Mar 2025