Context:  Hemodialys patients frequently experience the distressing side effects of restless legs syndrome and intradialytic hypotension. It may induce patients to experience discomforting symptoms, lead to vascular access thrombosis, and reduce the efficiency of dialysis. So, it is necessary to prevent this complication. Aim: The purpose of this research was to evaluate effect of   application of cool dialysate on controlling   hypotension and restless leg syndrome among patients undergoinghemodialysis.  Methods: A purposive sample of 88 patients admitted to the Hemodialys department at Benha University Hospital Qalyoubia, Egypt, was subjected to a quasi-experimental research design (control group and study). Three tools were used, I: Structured Interviewing Questionnaires, II: and intradialytic hypotension Assessment, and III: International restless legs syndrome Severity Rating Scale. Results demonstrated that the incidence of intradialytic hypotension signs and symptoms after the second and fourth weeks of intervention differed significantly between patients in study and control groups, with a statistically significant P-value of 0.003. Also, that there were high statistically significant differences between patients of both groups regarding total level of restless legs syndrome post-intervention (2^nd  and 4^th week), with a statistically significant    P-value of <0.001** Conclusion: Application of cool dialysate controlled  intradialytic hypotension and restless legs syndrome among study hemodialysis patient compared to control group. Recommendations: Similar studies should be replicated on a large sample size in different geographic areas in Egypt to generalize the findings.