Introduction: Maxillofacial surgeons usually face difficulty in treating odontogenic
keratocysts since it has a high risk of recurrence and are small and delicate, which
prevents one-piece enucleation. Aim: To assess the effectiveness of modified Carnoy's
solution as a chemical curettage method for treating Odontogenic Keratocysts and
lowering their propensity to recur. Material and Methods: The current study included
twelve patients diagnosed with having odontogenic keratocysts either in the maxilla
or mandible. The lesion was enucleated and any teeth adhering to the lesion were
removed. Modified Carnoy's solution was applied for 3-5 min using ribbon gauze or
cotton applicators in the bony cavity and the fenestrated area where excision of the
overlying soft tissue was not possible. After thorough irrigation with saline, then the
wound was closed with a resorbable suture. During the follow-up visits (six and twelve
months after surgery), the presence and/or rate of recurrence were examined clinically
and radiographically by panoramic radiography to evaluate presence of osteolytic
areas in the surgical site. Results: The recurrence rate of odontogenic keratocysts in
the present study after six months follow up was 8.3% and after twelve months follow
up was 33.3%. Eight patients showed no recurrence after twelve months follow up,
while one patient showed recurrence after six months and the remaining three patients
showed recurrence after twelve months follow up. Conclusion: The recurrence rate of
OKC was reduced in the current trial using a modified version of Carnoy's solution,
nevertheless, it is still considered high compared to conventional treatment techniques.