Background: The adoption of Hospital Information Systems (HIS) is crucial for keeping up with
technological advancements in daily life, especially in the healthcare sector, to improve the quality of
care for patients. A deep understanding of the factors that influence the acceptance of these systems
can greatly aid healthcare providers (HCPs) in successfully and effectively implementing them. Aim:
To explore factors associated with the utilization and acceptance of Hospital Information Systems
from healthcare providers' perspectives. Settings: The study was carried out in The Alexandria
Urology Hospital. Subjects: All health care providers who are working in the previously mentioned
setting. Subjects were divided into categories based on their job titles (Nursing staff, technical staff,
Physicians, Pharmacist). Tool: Hospital information system utilization and acceptance questionnaire
Results: The study showed that there was a statistically positive significant correlation between The
Acceptance and The Utilization of HIS (r=0.740, p=0.000). Also, statistically positive significant
relationships between all dimensions of The Utilization and The Acceptance of HIS). Conclusion: The
mean score of utilization and acceptance of HIS By domains, indicates a relatively high level among
HCPs which explains that the highest mean score is related to the Perceived usefulness domain while
the lowest mean score is related to the Organizational factors domain. Recommendations: Improving
the organizational structure in the hospital in terms of continuous training and guidance to HCPs on
the optimal use of the system and providing all operating requirements.