Background: The presence of agitation often obscures the accurate diagnosis and postpones
the initiation of treatment of critically ill patients. To mitigate the negative consequences of agitation,
multi-component nursing interventions were tailored for these patients. Those are evidence-based
interventions that address the unique needs, preferences, and values of patients. Aim: To
determine the effect of multi-component nursing intervention on agitation level among critically ill
patients. Settings: This study was conducted across four adult intensive care units ICUs located within
Alexandria Main University Hospital (AMUH) in Egypt. Subjects: A convenient sample consisting of
60 critically ill patients was divided into two equal groups, with each group comprising 30 patients.
Tools: Three tools were employed in this study. The first tool was the "agitation risk assessment". The
second tool utilized was the "outcomes of multi-Component nursing intervention on agitation". The
third tool applied was the "agitation adverse events Assessment". Results: The study results showed
that the frequency of agitation was significantly reduced in the multi-component intervention group
compared to the routine care group on days 4 and 5 (p = (p=<0.018 and 0.035, respectively).
Furthermore, agitation levels over five days did not differ significantly between the multi-component
intervention group and the routine care group (p=0.077, 0.516, 0.492, 0.274, and 0.684, respectively).
Conclusion: Implementation of a multi-component nursing intervention significantly reduced the
frequency of agitation. Recommendations: Critical care nurses (CCNs) should integrate multicomponent
nursing interventions into their daily practice that tailored to the patient's needs and
preferences.