Background: ITP can impact on many aspects of patients' life such as work, relationships and daily
living. Proper nursing guidance can enhance the quality of life and reduce bleeding incidence. Aim:
Evaluate the effect of self care guidance on quality of life and bleeding incidence for patients with
immune thrombocytopenia. Design: A quasi experimental design was used. Sample: 60 adult patients
were randomly assigned into 2 equal groups, 30 study and 30 control. Setting: The study conducted
Internal medicine department and Hematological outpatient clinic at Assiut University Hospital. Tools:
(I): Patient's assessment sheet, (II): ITP Life Quality Index (ILQI) and (III): The ITP Bleeding Scale
(IBLS). Results: A statistically significant differences between study and control groups related to
quality of life and bleeding incidence post implementation of self care guidance. Conclusion: The
implementation of self care guidance has a positive effect on patient quality of life and reduce bleeding
incidence. Recommendations: self care guidance should serve as the basis for routine nursing care for
patients with immune thrombocytopenia to improve their quality of life and reduce bleeding incidence.