Preeclampsia is a pregnancy-related syndrome that is one of the frequent reasons for neonatal and maternal deaths and illness throughout the world. Preeclampsia affects roughly 2% to 8% of all pregnancies, resulting in more than 63,000 maternal fatalities per year around the world. Early detection of preeclampsia would allow for intervention and attentive monitoring, reducing the disorder's negative implications. The present study, aimed to evaluate the role of maternal serum uric acid and calcium versus Umbilical artery Doppler blood flow in preeclamptic patients at 28-30 weeks of gestation compared to Normotensive pregnant participants at El-Shatby Maternity University Hospital. There were significant negative correlations between serum calcium and UAPI across both preeclampsia groupings (mild and severe). Moreover, a significant positive correlations between serum uric acid and UAPI in both mild and severe preeclampsia groups. The preeclampsia group exhibited a significant decline in serum calcium levels, whereas serum uric acid levels and umbilical artery Doppler parameters showed a significant increase. These variations were more detectable in severe preeclampsia, suggesting their potential use as a predictive marker for preeclampsia severity.