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386679

Topical Tea Tree Oil versus Systemic Azithromycin in the Treatment of Posterior Marginal Blepharitis

Article

Last updated: 09 Mar 2025

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Abstract

Purpose: To compare between the effectiveness of systemic azithromycin and topical tea tree oil in treating posterior marginal blepharitis. Design: prospective comparative research. Participants: sixty cases suffering from posterior marginal blepharitis, assigned into 2 groups, each one comprised thirty cases. Methods: Group I applied TTO once daily at bedtime. Group II administered oral azithromycin once daily before breakfast for six days and all patients applied topical lubricant eye drops five times daily. The tear film break-up time, ocular symptoms, Schirmer's test and eyelid margin signs have been assessed at baseline and five weeks later. Results: Each group was sub-divided into (severe) and (mild to moderate) sub-groups, then we compared the baseline data of (severe) sub-groups and (mild to moderate) sub-groups. Insignificant variance was observed in results regarding symptoms, signs, Schirmer's test and TBUT. Five weeks after receiving treatment, we collected patients' data same as first visit. We compared the data in first and second visits in each sub group and significant variance was observed in both groups. We compared results in severe sub-groups, significant variance was observed regarding symptoms (p < 0.001), signs (p < 0.001), TBUT test (p < 0.001) and Schirmer's test (p < 0.001). We compared results in mild to moderate sub-groups and significant variance was observed according to symptoms (p < 0.001), signs (p < 0.001), TBUT test (p < 0.001) and Schirmer's test (p < 0.001). Conclusions: Both TTO and oral azithromycin are effective in treating posterior marginal blepharitis with higher efficacy of TTO.

DOI

10.21608/bmfj.2024.321564.2203

Keywords

posterior marginal blepharitis, Tea tree oil, Azithromycin, Dry eye

Authors

First Name

Hamdy

Last Name

Elgazzar

MiddleName

Ahmed

Affiliation

Department of Ophthalmology, Faculty of Medicine, Benha University, Benha, Egypt

Email

hamdi.algazar@fmed.bu.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Mohammed Hussein

MiddleName

Abdelnaby

Affiliation

Department of Ophthalmology , Faculty of Medicine, Benha University, Benha, Egypt

Email

tohamy1125@gmail.com

City

-

Orcid

-

First Name

Taher

Last Name

Eleiwa

MiddleName

Kamal

Affiliation

Department of ophthalmology Faculty of Medicine - Banha University

Email

tahereleiwa87@gmail.com

City

-

Orcid

-

Volume

42

Article Issue

3

Related Issue

54154

Issue Date

2025-03-01

Receive Date

2024-09-17

Publish Date

2025-03-01

Page Start

155

Page End

167

Print ISSN

1110-208X

Online ISSN

2357-0016

Link

https://bmfj.journals.ekb.eg/article_386679.html

Detail API

http://journals.ekb.eg?_action=service&article_code=386679

Order

698

Type

Original Article

Type Code

787

Publication Type

Journal

Publication Title

Benha Medical Journal

Publication Link

https://bmfj.journals.ekb.eg/

MainTitle

Topical Tea Tree Oil versus Systemic Azithromycin in the Treatment of Posterior Marginal Blepharitis

Details

Type

Article

Created At

09 Mar 2025