Background: Despite the high clinical success rates of Calcium Hydroxide-Iodoform paste, its radiographic success rate is relatively low. Ethanol Alcohol irrigation is considered to potentially improve its efficacy compared to normal saline. Subjects and methods: 20 Children (4-7 years) diagnosed with decayed second primary mandibular molars experiencing irreversible pulpitis were selected randomly and were divided into two equal groups (n=10): The intervention group was (70% ethanol alcohol irrigation) and the control group was (normal saline irrigation).Post-operative pain was measured using the Visual Analog Scale (VAS). Clinical evaluations occurred at 3, 6, 9, and 12 months, while radiographic assessments were conducted at 6 and 12 months. Results: Both groups showed no significant difference in Visual Analog Scale (VAS). Clinically, ethanol alcohol had 100% success, while normal saline had a 90% success rate with one failure. Radiographically, both groups had a 90% failure rate at the 12-month follow-up, lacking statistical difference. Conclusion: There is no significant difference between 70% ethanol alcohol and normal saline as an intracanal irrigation solution in primary teeth with Calcium Hydroxide-Iodoform paste.