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414900

Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from <i>Pseudomonas aeruginosa</i> isolated from Mediterranean Sea, Alexandria, Egypt

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Last updated: 09 Mar 2025

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Abstract

In this study, four seawater and sediment samples were collected, Marine Pseudomonas aeruginosa (K3) was isolated from Alexandria, Egypt, and identified by using 16S rRNA gene sequencing and biochemical analyses. Optimization was carried out with various parameters to determine the optimum conditions to produce bio active compounds.   Pseudomonas aeruginosa k3 is known for producing bioactive compounds that are effective against a variety of pathogenic microorganisms, including Staphylococcus aureus (ATCC25923), Escherichia coli (ATCC 8739), Bacillus subtilis (ATCC 6633), Klebsiella pneumonia (ATCC 13883), Enterococcus faecalis (ATCC29212), Vibrio fluvialis (ATCC33809), and Pseudomonas aeruginosa (ATCC9027). GC-MS chromatography was used to identify the bioactive components. Additionally, we investigated the antiviral (HAV and CoxB4), anti-inflammatory (HRBC hemolysis and membrane stabilization), and anticancer (HepG2, Vero, and MCF-7) activity.

DOI

10.21608/mb.2025.322359.1173

Keywords

Antioxidant activity, bioactive metabolites, Cytotoxicity, Drug Discovery, Marine bacteria, secondary metabolites

Authors

First Name

Abdelraheem

Last Name

Mohamed

MiddleName

N.

Affiliation

South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt.

Email

abdelraheem444@gmail.com

City

-

Orcid

-

First Name

Abdel Kareem

Last Name

Mohamed

MiddleName

S.H.

Affiliation

Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Assiut 71111, Egypt.

Email

abdelkareemmohamed.42@azhar.edu.eg

City

-

Orcid

-

First Name

Asmaa

Last Name

Zahran

MiddleName

M.

Affiliation

Department of Clinical Pathology, South Egypt Cancer Institute, Assiut University, Assiut 71111, Egypt.

Email

asmaa.zahran@yahoo.com

City

-

Orcid

-

First Name

Ahmed

Last Name

Gad

MiddleName

Mohamed

Affiliation

National institute of Oceanography and Fisheries (NIOF), Qayed Bay, Anfoushy, Alexandria 21556, Egypt.

Email

a_gad7000@yahoo.com

City

-

Orcid

-

First Name

Alsayed

Last Name

Mekky

MiddleName

E.

Affiliation

Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City 11884, Cairo, Egypt.

Email

alsayedessam@azhar.edu.eg

City

-

Orcid

-

Volume

10

Article Issue

1

Related Issue

53711

Issue Date

2025-03-01

Receive Date

2024-09-19

Publish Date

2025-03-01

Print ISSN

2357-0326

Online ISSN

2357-0334

Link

https://mb.journals.ekb.eg/article_414900.html

Detail API

http://journals.ekb.eg?_action=service&article_code=414900

Order

414,900

Type

Original Article

Type Code

502

Publication Type

Journal

Publication Title

Microbial Biosystems

Publication Link

https://mb.journals.ekb.eg/

MainTitle

Antimicrobial, anti-inflammatory, anticancer and antiviral activity of bioactive compounds from <i>Pseudomonas aeruginosa</i> isolated from Mediterranean Sea, Alexandria, Egypt

Details

Type

Article

Created At

09 Mar 2025