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414605

Impact of Hepatitis a Virus Infection on the Liver in Children Infected in Upper Egypt, Case Control Study

Article

Last updated: 09 Mar 2025

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Subjects

-

Tags

virology

Abstract

Background: Infection with hepatitis A virus (HAV) occurs worldwide and is the most common cause of acute hepatitis. Egypt is considered an area of ​​high prevelance for HAV infection, with the highest prevalence of infection in early childhood. Objective: the aim of the work is to study the viral effect and pathophysiological changes in the liver as a result of HAV infection in children in Upper Egypt. Methodology: It is a case-control study of 250 children with suspected HAV infection confirmed by HAV-IgM using enzyme-linked immunosorbent assay (ELISA). In order to investigate liver pathophysiology before starting the treatment protocol, fifty affected children were randomly selected to undergo biochemical tests, including Alanine aminotransferase, Aspartate transaminase, alkaline phosphatase, Gamma glutamyl transpeptidase, total bilirubin, direct bilirubin, Lactate dehydrogenase, and total Leukocyte count. These tests were performed after 1 and 2 weeks of treatment, and the results were compared with 25 children who were confirmed to have no antibodies to HAV as proof. Result: Our results showed that 70 (28%) children were infected with hepatitis A virus. Our findings demonstrated that the levels of HAV-IgM, total Leukocyte count, Alanine aminotransferase, Aspartate transaminase, alkaline phosphatase, Gamma glutamyl transpeptidase, total bilirubin and direct bilirubin all had strong statistical significance between normal and HAV-infected children. While our results showed that there are no statistical differences between children after third week of treatment and normal children in in the level of HAV-IgM, total Leukocyte count, Alanine aminotransferase, Aspartate transaminase, alkaline phosphatase, Gamma glutamyl transpeptidase, total bilirubin and direct bilirubin. Accordingly, the vital functions of the liver improved to normal after the third week of treatment for HAV. Conclusion: After the third week of treatment (liver support, multivitamins), the liver functions of HAV infected children well be full recovered.

DOI

10.21608/ejmm.2025.358497.1469

Keywords

hepatitis A virus, HAV seroprevalence, anti-HAV-IgM

Authors

First Name

Mohey Eldin

Last Name

Shikhoun

MiddleName

H.

Affiliation

Analysis and Laboratories Department, Higher Technological Institute of Applied Health Sciences in Sohag, Ministry of Higher Education, Cairo, Egypt

Email

moheyshikhoun@gmail.com

City

-

Orcid

-

First Name

Ali

Last Name

Mohamed

MiddleName

A.A.

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University

Email

-

City

-

Orcid

-

First Name

Maha

Last Name

Ahmed

MiddleName

M.A.

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University

Email

-

City

-

Orcid

-

First Name

Abd elazim

Last Name

El shazly

MiddleName

M.

Affiliation

Gasteroenterology and Endoscopy Department, King Salman Hospital, Riyadh First Health Cluster, MOH, KSA

Email

-

City

-

Orcid

-

First Name

Noha

Last Name

Abd El Rahman

MiddleName

M.

Affiliation

Department of Tropical Medicine and Gastroenterology, Faculty of Medicine, Sohag University

Email

-

City

-

Orcid

-

Volume

34

Article Issue

3

Related Issue

53640

Issue Date

2025-07-01

Receive Date

2025-02-12

Publish Date

2025-07-01

Print ISSN

1110-2179

Online ISSN

2537-0979

Link

https://ejmm.journals.ekb.eg/article_414605.html

Detail API

http://journals.ekb.eg?_action=service&article_code=414605

Order

414,605

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Impact of Hepatitis a Virus Infection on the Liver in Children Infected in Upper Egypt, Case Control Study

Details

Type

Article

Created At

09 Mar 2025