Background: A number of factors, including hormones, smooth muscle injury, growth factors, and genetic predisposition, are linked to the creation of uterine fibroids, which are common benign tumors of the uterus made of smooth muscle and connective tissue. Myomectomy has historically been done as an open laparotomy; however, novel techniques, such as laparoscopic myomectomy (LM), have emerged in recent decades. Therefore, our goal was to compare the intraoperative and postoperative results of laparoscopic and abdominal approaches.

Methods: This cohort study was conducted at the Obstetrics and Gynecology Department, cytogenic and laparoscopic unit, Faculty of Medicine, Zagazig University, Egypt during the period from March 2023 to February 2024 on women having fibroid and complaining of heavy menstrual bleeding together with lower abdominal pain.

Results: Laparoscopic myomectomy, while associated with longer operative times, offers advantages in terms of shorter hospital stay and reduced post-operative pain compared to open myomectomy. The complication rates were similar between the two approaches.

Conclusion: We support the use of laparoscopic myomectomy as a safe and effective alternative to open myomectomy in appropriately selected patients.