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416272

Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sac

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Last updated: 09 Mar 2025

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Clinical Research (Medical)

Abstract

Background:We investigated the early improvement signs of LV systolic functions in symptomatic patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) at 3 months and 6 months after taking sacubitril/valsartan (S/V) therapy. Materials and Methods: Prospective study was done on 51 HFrEF patients receiving S/V. Baseline, 3- and 6-months evaluations were performed with routine 2D echocardiography and STE. LVEF and global longitudinal strain (GLS) were measured. Predictive value of STE was compared with routine echocardiography. Results: After three months, 71.1% of patients revealed LV function improvement by STE, compared to only 56.25% detected by standard 2d echo. 2d speckle tracking detected early improvement in 43.75% of patients who were not yet manifested by conventional 2d Echo. After 6 months, STE continued to identify improvement in 15.6% of patients not detected by standard echocardiography. The agreement between STE and standard echocardiography was very good (k=0.892). Moreover, 28.9% of study population didn't show response to SV by STE, and also none of them showed response by standard echocardiography, indicating that STE has a very good negative predictive value. Conclusion: STE is effective tool in early detection of LV systolic function improvement in comparison to standard 2D echocardiography, among patients with HFrEF receiving Sacubitril/valsartan therapy.

DOI

10.21608/scumj.2024.416272

Keywords

HFrEF, sacubitril/valsartan, Speckle tracking echocardiography

Authors

First Name

Mohammed

Last Name

El Merry

MiddleName

A.

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal university, Ismailia, Egypt

Email

m25merry@gmail.com

City

-

Orcid

0009-0002-4499-1611

First Name

Ahmed

Last Name

Al Hawary

MiddleName

A.

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal university, Ismailia, Egypt.

Email

-

City

-

Orcid

-

First Name

Khaled

Last Name

Abdelaziz

MiddleName

-

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal university, Ismailia, Egypt

Email

-

City

-

Orcid

-

First Name

Mohamed

Last Name

Abdel Shafee

MiddleName

A.

Affiliation

Department of Cardiology, Faculty of Medicine, Suez Canal university, Ismailia, Egypt

Email

epshawy@gmail.com

City

-

Orcid

-

Volume

27

Article Issue

10

Related Issue

52242

Issue Date

2024-10-01

Publish Date

2024-10-01

Page Start

1

Page End

7

Print ISSN

1110-6999

Online ISSN

2090-2581

Article File

SCUMJ_Volume 27_Issue 10_Pages 1-7.pdf

PDF . 344.2kB

Link

https://scumj.journals.ekb.eg/article_416272.html

Detail API

http://journals.ekb.eg?_action=service&article_code=416272

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Original Article

Type Code

938

Publication Type

Journal

Publication Title

Suez Canal University Medical Journal

Publication Link

https://scumj.journals.ekb.eg/

MainTitle

Role of Speckle Tracking Echocardiography in Early Detection of Left Ventricular Systolic Function Improvement in Heart Failure Patients with Reduced Ejection Fraction Taking Sac

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Type

Article

Created At

09 Mar 2025