Background: Peripheral neuropathy is common unpleasant events associated with cancer treatment, the use of multi non-pharmacological methods in the prevention and treatment of that problem provide advantages like controlling neuropathy pain, as well enhancing functional ability and emotional distress. Aim: To examine the effectiveness of multi-modal nursing practices on pain, functional ability and emotional distress among women with peripheral neuropathy related chemotherapy. Design: Quasi experimental design was used. Setting: Chemotherapy unit at National Cancer Institute in Menoufia University, Egypt. Subject: A purposive sample of 90 women receives chemotherapy induced peripheral neuropathy were chosen. Tools for data collection: Five tools encompassed: Sociodemographic Properties Questionnaire; Chemotherapy Induced Peripheral Neuropathy Scale, The Brief Pain Inventory, Functional Ability Scale and Perceived Emotional Distress Scale. Results: There were statistical significant differences on post intervention among study compared to control groups respectively, in the total mean scores of pain 4.73±1.80& 6.20±1.60; functional abilities' scale 93.33±10.19& 79.93±15.66; perceived emotional distress 21.58±5.92 & 24.9±8.1 and chemotherapy induced peripheral 76.00±11.32 & 82.89±12.66 (p<0.05). In addition, there were positive significance correlation between pain; emotional distress and level of chemotherapy-induced peripheral neuropathy. Alongside, there was negative significant correlation between functional ability and level of chemotherapy-induced peripheral neuropathy p<0.001on post intervention among study than in control groups. Conclusion: Multimodal nursing practices are beneficial in the management of women with cancer breast receiving chemo-therapy induced peripheral neuropathy. Recommendation: Implement multimodal nursing practices as standard protocol in managing breast cancer women with peripheral neuropathy related chemotherapy in the different study settings.