This article presents an integrative review of 12 novel hypotheses related to the biology of aging and potential interventions to extend healthy lifespan. The hypotheses cover diverse topics including electromagnetic fields, cellular energetics, gastrointestinal function, and monitoring of age-related changes. A comprehensive literature review was conducted to evaluate the scientific basis and evidence for each hypothesis. While many of the proposed mechanisms require further research to validate, several show promise as avenues for future aging interventions. Key themes that emerged include the importance of mitochondrial function, hormesis, and systems-level integration in the aging process. This review synthesizes these emerging theories and discusses their implications for gerontology research and clinical applications in healthy aging.