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415942

Role of miRNA-182 and 187 as Diagnostic and Prognostic Biomarkers for Prostate Cancer

Article

Last updated: 09 Apr 2025

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-

Tags

Clinical microbiology

Abstract

Background: Prostate cancer (PC) remains a leading malignancy in men, necessitating the discovery of novel non-invasive biomarkers for early detection and monitoring. Objectives: This study evaluates the diagnostic and prognostic role of microRNAs (miRNA-182 and miRNA-187) in differentiating PC from benign prostatic hyperplasia (BPH). Methodology: A prospective observational study was conducted over 24 months at the Urology and Nephrology Center, Mansoura University, enrolling 110 male patients aged 50–80 years. Participants were categorized into three groups: newly diagnosed PC patients (n=40), BPH patients (n=30), and post-treatment PC patients (n=40). Clinical assessments, prostate-specific antigen (PSA) measurements, and quantitative real-time PCR (qRT-PCR) for miRNA-182 and miRNA-187 expression were performed. Results: miRNA-182 levels were significantly elevated in PC patients (median: 2.80, range: 1.18–6.36) compared to BPH patients (median: 1.65, range: 0.7–2.35, P < 0.049). Following treatment, miRNA-182 levels declined significantly (median: 0.78, range: 0.23–3.01, P = 0.049), paralleling PSA reduction. No significant differences in miRNA-182 levels were observed between PC patients with and without bone metastases. Conversely, miRNA-187 was undetectable in all studied samples, suggesting its limited role as a biomarker. Conclusion: miRNA-182 demonstrates potential as a diagnostic and prognostic biomarker for PC, showing elevated expression in cancerous states and a significant decline post-treatment. However, miRNA-187 appears non-contributory in this context. Further large-scale studies are required to support the findings of this study and explore their clinical utility in PC management.

DOI

10.21608/ejmm.2025.362103.1489

Keywords

Prostate Cancer, microRNA-182, microRNA-187, biomarker, qRT-PCR

Authors

First Name

Doaa

Last Name

Riad

MiddleName

M.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Damietta University, Damietta, Egypt

Email

doaariad90.dr@gmail.com

City

-

Orcid

-

First Name

Raghdaa

Last Name

Shrief

MiddleName

N.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Damietta University, Damietta, Egypt

Email

r.shrief77@gmail.com

City

-

Orcid

-

First Name

Medhat

Last Name

El-Daker

MiddleName

-

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

meldaker@yahoo.com

City

-

Orcid

-

First Name

Hassan

Last Name

Abol-Enein

MiddleName

-

Affiliation

Urology Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

hassanabolenein@hotmail.com

City

-

Orcid

-

First Name

Hazem

Last Name

Saleh

MiddleName

H.

Affiliation

Laboratory Department, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt

Email

hazemhamed@mans.edu.eg

City

-

Orcid

-

First Name

Fikry

Last Name

El-Morsy

MiddleName

E.

Affiliation

Medical Microbiology and Immunology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt

Email

drfikry52@gmail.com

City

-

Orcid

-

Volume

34

Article Issue

2

Related Issue

51523

Issue Date

2025-04-01

Receive Date

2025-02-20

Publish Date

2025-04-01

Page Start

373

Page End

379

Print ISSN

1110-2179

Online ISSN

2537-0979

Article File

EJMM_Volume 34_Issue 2_Pages 373-379.pdf

PDF . 265.9kB

Link

https://ejmm.journals.ekb.eg/article_415942.html

Detail API

http://journals.ekb.eg?_action=service&article_code=415942

Order

415,942

Type

New and original researches in the field of Microbiology.

Type Code

2,038

Publication Type

Journal

Publication Title

Egyptian Journal of Medical Microbiology

Publication Link

https://ejmm.journals.ekb.eg/

MainTitle

Role of miRNA-182 and 187 as Diagnostic and Prognostic Biomarkers for Prostate Cancer

Details

Type

Article

Created At

09 Mar 2025