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Neuroprotective Impact of Baicalein on Scopolamine Induced Cognitive Deficits Targeting PI3K/Akt /NF-kB pathway

Article

Last updated: 09 Mar 2025

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Subjects

-

Tags

Experimental Toxicology

Abstract

Dementia is a substantial public health concern. Scopolamine (Scop) is a muscarinic acetylcholine receptor antagonist that induces cognitive impairment. The objective of this study was to demonstrate the potential mechanisms by which Baicalein (Baic) might protect against cognitive abnormalities caused by Scop. The thirty male albino rats were divided into three groups: Scop, Scop plus Baic, and control (10/group). After four weeks neurobehavioral assessment was conducted in conjunction with the measurement of hippocampal MDA, SOD, acetylcholine, BDNF, TNF-α, IL-6, IL-1β, and PI3K, Akt, and NF-kB gene expression. The immunohistochemical analysis of Bax, Tau, and GFAP markers was assessed. Scop induced cognitive impairment in rats with a significant increase in the expression of MDA, TNF-α, IL-6, IL-1β, and NF-kB genes, as well as a substantial decrease in the expression of hippocampal SOD, BDNF, acetylcholine, and hippocampal PI3K and Akt genes, as well as an upregulation of GFAP, Tau, and Bax immunoreactions, however Baic dramatically improved Scop-induced cognitive impairment. We can conclude that Baic induced anti-oxidant, anti-inflammatory, neurotrophic, and anti-apoptotic mechanisms in addition to modifying the PI3K/Akt/NF-kB signaling cascade to mitigate the cognitive impairments brought on by Scop.

DOI

10.21608/mjfmct.2024.333801.1088

Keywords

Akt, Baicalein, NF-kB, Scopolamine, PI3K

Authors

First Name

Suzan

Last Name

Khodir

MiddleName

A

Affiliation

Physiology Department, Faculty of Medicine, Menoufia University, Egypt

Email

suzan.abdalhameed.12@med.menofia.edu.eg

City

menoufia

Orcid

0000-0002-2535-9445

First Name

Alaa

Last Name

Nagy

MiddleName

-

Affiliation

Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Egypt

Email

hashema877@yahoo.com

City

-

Orcid

-

First Name

ola

Last Name

Mohamed

MiddleName

-

Affiliation

Pharmacology Department, Faculty of Medicine, Suez Canal University, Egypt

Email

hashem877@yahoo.com

City

-

Orcid

-

First Name

noha

Last Name

Abd El-aziz

MiddleName

-

Affiliation

Anatomy and Embryology Department, Faculty of Medicine, Menoufia University, Egypt

Email

rose_a.hashem256@yahoo.com

City

-

Orcid

-

First Name

fatma

Last Name

ahmed

MiddleName

-

Affiliation

Clinical Pharmacology Department, Faculty of medicine, Menoufia University

Email

fatma.shehata@med.menofia.edu.eg

City

-

Orcid

-

First Name

mohamed

Last Name

zayed

MiddleName

-

Affiliation

Medical Physiology Department, Faculty of Medicine, Menoufia University, Egypt Medical Physiology Department, Faculty of Medicine, King Abdulaziz University, KSA

Email

soso_egy89@gmail.com

City

-

Orcid

-

First Name

walaa

Last Name

Elgheriany

MiddleName

-

Affiliation

Internal Medicine Department Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt.

Email

suzy25186@gmail.com

City

-

Orcid

-

First Name

tarek

Last Name

Abd-Elhamid

MiddleName

-

Affiliation

Histology and Cell Biology, Faculty of Medicine, Assiut University Histology, Faculty of Medicine, Aqaba Medical Sciences University

Email

soso_egy89@yahoo.com

City

-

Orcid

-

First Name

hend

Last Name

Omara

MiddleName

-

Affiliation

Psychiatry Department, Faculty of Medicine, Menoufia University, Egypt

Email

suzy25186@yahoo.com

City

-

Orcid

-

First Name

asmaa

Last Name

Bayomi

MiddleName

-

Affiliation

Zoology Department - Faculty of Science, Menoufia University, Egypt

Email

asmaabolty@yahoo.com

City

-

Orcid

-

First Name

haidy

Last Name

Abouhatab

MiddleName

-

Affiliation

Forensic Medicine and Clinical Toxicology, Department, Faculty of Medicine, Menoufia University, Egypt

Email

soso_egy@yahoo.com

City

-

Orcid

-

First Name

Karema

Last Name

Diab

MiddleName

Abdelhady

Affiliation

Clinical Pathology Department, National Liver Institute, Menoufia University, Egypt

Email

karemadiab6@yahoo.com

City

-

Orcid

-

First Name

Samar

Last Name

Hussein

MiddleName

M

Affiliation

Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt

Email

samarhussein@med.suez.edu.eg

City

-

Orcid

-

Volume

33

Article Issue

1

Related Issue

51128

Issue Date

2025-01-01

Receive Date

2024-11-05

Publish Date

2025-01-01

Page Start

45

Page End

59

Print ISSN

1110-5437

Online ISSN

2682-3217

Article File

MJFMCT_Volume 33_Issue 1_Pages 45-59.pdf

PDF . 1.3MB

Link

https://mjfmct.journals.ekb.eg/article_403017.html

Detail API

http://journals.ekb.eg?_action=service&article_code=403017

Order

403,017

Type

Original Article

Type Code

966

Publication Type

Journal

Publication Title

Mansoura Journal of Forensic Medicine and Clinical Toxicology

Publication Link

https://mjfmct.journals.ekb.eg/

MainTitle

Neuroprotective Impact of Baicalein on Scopolamine Induced Cognitive Deficits Targeting PI3K/Akt /NF-kB pathway

Details

Type

Article

Created At

09 Mar 2025