Psoriasis is a chronic autoimmune non-communicable inflammatory skin condition. High stages of self-care are necessary for psoriasis to improve health outcomes. Aim: This study aimed to evaluate the effectiveness of innovative electronic health education program regarding self-care practices for psoriasis patients. Design: A quasi- experimental design was used. Setting: It was conducted at outpatient clinics in Al Houd El Marsoud Hospital for Dermatology and Venereology, Cairo, Egypt. Sample: Purposive sample include 110 patients diagnosed with psoriasis. Tools of data collection: Two tools, 1^st tool: A structured interviewing questionnaire covering three parts: Part 1: Demographic characteristics of patients, Part 2: Past and present medial history of patients, Part 3: Patients' knowledge about psoriasis. 2^nd Tool: Patients' self-care reported practices about psoriasis. Results: The study results revealed that, 10.9 % of studied patients had good total knowledge pre apply electronic health education program, which improved to 86.4 % of them had good total knowledge post program. While, 47% of them had adequate self- care reported practices at pre apply electronic health education program, which improved to 92% of them had adequate self- care reported practices at post with highly statistically significant improvement. There was a highly statistically significant correlation between total knowledge level and total self- care reported practices level of studied patients at post electronic health education program about psoriasis Conclusion: There was an improvement in patients' total knowledge and total self-care reported practices after implementation of innovative electronic health education program. Recommendation: Continues health education program to enhance awareness of patients about psoriasis.